Melatonin Inhibits the Central Sympatho-adrenomedullary Outflow in Rats
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概要
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Central effects of melatonin on the sympatho-adrenomedullary outflow were investigated in urethane-anesthetized rats. In the intact animals, intracerebroventricularly (i.c.v.) administered interleukin-1β (IL-1β) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Melatonin (100 βg/animal, i.c.v.) did not modulate the effects of IL-1β on plasma levels of catecholamines. In the pinealectomized animals, however, the same dose of IL-1β markedly elevated plasma levels of both Ad and NA, and the elevation of Ad was more potent than that of NA. In these pinealectomized animals, the serum level of melatonin was significantly lower than that in the sham-operated control animals. Furthermore, the IL-1β-induced elevations of plasma catecholamines in these pinealectomized animals were attenuated by i.c.v. administered melatonin. These results suggest that melatonin plays an inhibitory role in the central regulation of sympatho-adrenomedullary outflow in rats.
- 社団法人 日本薬理学会の論文
著者
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YOKOTANI Kunihiko
Department of Pharmacology, School of Medicine, Kochi University
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Yokotani K
Kochi Medical School Kochi Jpn
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Yokotani Kunihiko
Department Of Pharmacology Kochi Medical School
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Murakami Yoshinori
Department Of Pharmacology Kochi Medical School
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WANG Muchun
Department of Pharmacology, Kochi Medical School
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OKADA Shoshiro
Department of Pharmacology, Kochi Medical School
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NAKAMURA Kumiko
Department of Pharmacology, Kochi Medical School
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OSUMI Yoshitsugu
Department of Pharmacology, Kochi Medical School
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Murakami Yoshinori
Department Of Chemistry Nagaoka University Of Technology
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Wang Muchun
Department Of Pharmacology Kochi Medical School
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Wang Muchun
Department Of Otorhinolaryngology Kumamoto University School Of Medicine
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Okuma Y
Hokkaido Univ. Sapporo Jpn
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Okuma Yasunobu
Department Of Pharmacology Kochi Medical School
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Okada S
Department Of Pharmacology Kochi Medical School
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Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
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Nakamura Kumiko
Department Of Anesthesia And Intensive Care Medicine Yamaguchi Grand Medical Center
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Yokotani K
Department Of Pharmacology Kochi Medical School
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Osumi Yoshitsugu
Department Of Pharmacology Kochi Medical School
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Osumi Yoshitsugu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Yokotani Kunihiko
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
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Okada Shoshiro
Department of Neuropharmacology, Program of Neural Integration, Graduate School of Medicine, Kochi University
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