Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
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概要
- 論文の詳細を見る
It is generally agreed that the release of norepinephrine (NE) is inhibited by activation of prejunctional purinoceptor. We examined the pharmacological properties of purinoceptors on vascular sympathetic nerve terminals and the source of endogenous adenyl purines. Electrically (1 Hz) evoked NE-release was inhibited by not only P1-agonists but also P2-agonists. Although the inhibition induced by P2-agonists was blocked by P1-antagonists, P2-agonists-induced inhibition was not due to the breakdown to adenosine. Therefore, there may be a new class of purinoceptor that is activated by both P1- and P2-agonists and antagonized by P1-antagonists. Electrical stimulation at 8 Hz but not at 1 Hz evoked the release of adenyl purines such as ATP, ADP, AMP and adenosine, in addition to NE; and the purines-release was blocked by an α1-antagonist. Methoxamine, an α1-agonist, also evoked the release of purines. Electrically (1 Hz)-evoked NE-release was inhibited by methoxamine, and this inhibition was blocked by not only an α1-antagonist but also a P1-antagonist. Therefore, the activation of α1-adrenoceptor appeared to release purines, which in turn inhibited NE-release via prejunctional purinoceptors. From these results, it is suggested that the unique purinoceptor and the endogenous purines released from α1-adrenoceptor-sensitive sources participate in the antidromic transsynaptic modulation of vascular sympathetic neurotransmission.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
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Nakamura Katsuya
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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NAKAMURA Kazuki
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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Nakamura K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Mizuno Hideya
Department Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women 's University
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Mizuno Hideya
武庫川女子大学 薬 薬理
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Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Kunitomo Masaru
京都大学 医学研究科糖尿病･栄養内科学
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Nakamura Kazufumi
Faculty Of Pharmaceutical Sciences Kyushu University
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Kunitomo Masaru
Department Of Pharmacology Shizuoka College Of Pharmaceutical Science
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Nakamura Kazuki
Department Of Applied Chemistry Faculty Of Engineering Shibaura Institute Of Technology
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Nakamura Katsuji
Tsukuba Research Laboratories Eisai Co. Ltd.
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Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
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Nakamura K
Department Of Physiology Ii Iwate Medical University School Of Medicine
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Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
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Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
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Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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