Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with .BETA.-aminopropionitrile: Effects of various anti-atherosclerotic agents on the biochemical parameters.
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概要
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A mouse model of atherosclerosis was produced by feeding a 1.5% cholesterol diet with 0.4% β-aminopropionitrile (BAPN) fumarate, a chemical lathyrogen, for 10 weeks, and the pharmacological sensitivity and specificity of this model were evaluated biochemically with various hypolipidemic drugs and calcium antagonists. Histological findings on this model showed typical angiolathyrism with foam cells in the media of the thoracic aorta. Uniform and marked accumulation of cholesterol, notably esterified cholesterol, in the aorta was observed, although it was much less in mice receiving a high-cholesterol diet or BAPN alone. The reduction in elastin contents in the aorta was a characteristic feature of this model. Clofibrate, cetaben and elastase tended to prevent the increase of cholesterol contents in the aorta, together with their significant hypocholesterolemic effects. Nifedipine, diltiazem and verapamil showed a slight preventive effect on the cholesterol accumulation and on the reduction of elastin content in the aorta without a cholesterol lowering effect in the serum. MgCl<SUB>2</SUB> was more effective than other calcium antagonists and even had a hypocholesterolemic effect. The results indicate that this mouse atherosclerosis model may be usable for primary drug evaluation.
- 公益社団法人 日本薬理学会の論文
著者
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Yamaguchi Yu
Department Of Obstetrics And Gynecology Tohoku University School Of Medicine
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Yamada Kaori
Department Of Biological Science And Technology Tokai University
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KITAGAWA Satomi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Kitagawa Satomi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women''s University
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