Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
スポンサーリンク
概要
- 論文の詳細を見る
We examined the release of endogenous adenyl purines such as adenosine triphosphate (ATP), ADP, AMP and adenosine from the caudal artery (CA), saphenous artery (SA), renal artery (RA), mesenteric artery (MA), pulmonary artery (PA) and thoracic aorta (TA) of rats, using high-performance liquid chromatography fluorescence detection. Noradrenaline induced the release of adenyl purines from these blood vessels. The total amount of adenyl purines release induced by noradrenaline from the CA was considerably larger than that from the TA. The rank order of the amount of adenyl purines released from the six blood vessels was CA>SA>RA>MA>PA≧TA. The noradrenaline-induced release of adenyl purines from the CA was significantly reduced by the removal of the endothelium. Noradrenaline also induced the release of adenyl purines from cultured endothelial cells of the CA and TA. The total amount of adenyl purines released from the former blood vessel was much larger than that from the latter. These results suggest the existence of vascular endothelial cells that are able to release ATP by an α_1-adrenoceptor mediated mechanism, and that these cells are not homogeneously distributed in the vasculature.
- 日本平滑筋学会の論文
著者
-
KWON Young
Department of Mechano-Informatics & Design Engineering, Hongik University
-
KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
SHINOZUKA Kazumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
Kunimoto M
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kunitomo Masaru
京都大学 医学研究科糖尿病･栄養内科学
-
Kubota Y
Department Of Biopharmaceutics Nihon Pharmaceutical University
-
HASHIMOTO Michio
Department of Physiology, Shimane Medical University
-
MASUMURA Sumio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
-
BJUR Richard
Department of Pharmacology, University of Nevada School of Medicine
-
WESTFALL David
Department of Pharmacology, University of Nevada School of Medicine
-
Bjur Richard
Department Of Pharmacology University Of Nevada School Of Medicine
-
Westfall David
Department Of Pharmacology University Of Nevada School Of Medicine
-
Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Hashimoto Michio
Department Of Physiology Shimane Medical University
-
Hashimoto Michio
Department Of Environmental Physiology Faculty Of Medicine Shimane University
-
Shinozuka Kazumasa
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Shinozuka Kazumasa
Dep. Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Shinozuka Kazumasa
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
-
Shinozuka Kazumasa
Department Of Pharmacology Faculty Of Pharmaceutical Science Mukogawa Women's University
-
Shinozuka K
Department Of Pharmacology School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ
-
Kwon Young
Department Of Biopharmaceutics Nihon Pharmaceutical University
-
Kunitomo Masaru
Dep. Of Pharmacology School Of Pharmaceutical Sciences Mukogawa Women's Univ. Jpn
-
Shinozuka Kazumasa
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
関連論文
- Effects of Dietary Ingredients on Function and Expression of P-Glycoprotein in Human Intestinal Epithelial Cells
- Characterization of cardiac size and function in SHRSP.Z-Lepr[fa]/IzmDmcr rats, a new animal model of metabolic syndrome
- Finite Element Stress Analysis of Spent Nuclear Fuel Disposal Canister in a Deep Geological Repository
- ON COMPLETELY REGULAR AND QUASI-COMPLETELY REGULAR ORDERED SEMIGROUPS
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Safety of Dietary Supplements:Chronotropic and Inotropic Effects on Isolated Rat Atria
- Biochemical Evidence of Atherosclerosis Progression Mediated by Increased Oxidative Stress in Apolipoprotein E-Deficient Spontaneously Hyperlipidemic Mice Exposed to Chronic Cigarette Smoke
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Inhibitory Effect of Cordyceps sinensis on Spontaneous Liver Metastasis of Lewis Lung Carcinoma and B16 Melanoma Cells
- Beneficial Effect of Coenzyme Q10 on Increased Oxidative and Nitrative Stress and Inflammation and Individual Metabolic Components Developing in a Rat Model of Metabolic Syndrome
- Anion-exchange high-performance liquid chromatography assays of plasma lipoproteins and modified low-density lipoproteins using a ProtEx-DEAE column
- Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
- High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modified lipoproteins
- Anion-exchange high-performance liquid chromatographic assay of plasma lipoproteins of rabbits, rats and mice
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- High-Spin States in ^Nb(Nuclear physics)
- Characterization of Cardiac Size and Function in SHRSP.Z-Leprfa/IzmDmcr Rats, a New Animal Model of Metabolic Syndrome
- Highly Sensitive Measurement of P-Glycoprotein-Mediated Transport Activity in Caco-2 Cells
- Effect of Vanadate on ATP-Induced Increase in Intracellular Calcium Ion Levels in Human Umbilical Vein Endothelial Cells
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line(Biochemistry)
- Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect
- Oxidants in the Gas Phase of Cigarette Smoke Pass Through the Lung Alveolar Wall and Raise Systemic Oxidative Stress
- EFFECT OF SHAKUYAKU-KANZOH-TOH, A PRESCRIPTION COMPOSED OF SHAKUYAKU (PAEONIAE RADIX) AND KANZOH (GLYCYRRHIZAE RADIX) ON GUINEA PIG ILEUM
- Determining the Self-Assembling and Redox Process of a Viologen Monolayer by Electrochemical Quartz Crystal Microbalance
- Electrical Transport Properties of Au-Doped Deoxyribonucleic Acid Molecules
- Characteristics of contractile activity in the renal artery of ovariectomized rats
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Seismic Intensity and Mental Stress after the Great Hanshin-Awaji Earthquake
- Life Events and Posttraumatic Stress in Hanshin-Awaji Earthquake Victims
- Involvement of Inducible Nitric Oxide Synthase in Blood Flow Decrease in Vein Induced by Hen-Egg White Lysozyme(Miscellaneous)
- Development of an in Vivo Bioassay Method for Allergy-Preventive Substances Using Hen-Egg White Lysozyme (HEL)-Induced Blood Flow Decrease(Miscellaneous)
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Demographic and Socioeconomic Determinants of the Use of Periodic Health Examinations : Public vs. Private Sector
- The Benefits of Supplementary Private Health Insurance for Healthcare Utilization and Survival among Stomach Cancer Patients
- Comparative Study of Arteriosclerosis between Brain and Heart, with Special Reference to the Cerebrovascular and Coronary Heart Disease
- Contribution of the Suprachiasmatic Nucleus to the Formation of a Time Memory for Heat Exposure in Rats
- Anticipatory Fall in Core Temperature in Rats Acclimated to Heat Given for Various Hours at a Fixed Daily Time
- Carotenoid, Tocopherol, and Fatty Acid Biomarkers and Dietary Intake Estimated by Using a Brief Self-Administered Diet History Questionnaire for Older Japanese Children and Adolescents
- Relationship between Large and Small Arterial Compliance and Regional Body Composition in Middle-Aged and Elderly Adults
- Plasma n-3 Polyunsaturated Fatty Acid and Cardiovascular Disease Risk Factors in Japanese, Korean and Mongolian Workers
- An Autopsy Case of Idiopathic Myocardial Hypertrophy, the Heart Weight of which indicated 1,000 gr
- Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
- POSSIBILITIES FOR ADENOSINE MODULATION OF PERISTALTIC REFLEX IN GUINEA PIG ISOLATED ILEUM
- PHYSIOLOGICAL IMPLICATION OF THE L-ARGININE-NITRIC OXIDE PATHWAY IN CIRCULATION
- Are Low Total Serum Antioxidant Status and Elevated Levels of C-Reactive Protein and Monocyte Chemotactic Protein-1 Associated With Cardiac Syndrome X?
- Participation of Endogenous Noradrenaline in the Relaese of ATP by High Potassium in the Rat Caudal Artery
- Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases:Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease
- THE INFLUENCE OF EXTRACELLULAR Ca2+ CONCENTRATION ON THE INHIBITORY EFFECT OF ADENOSINE IN GUINEA-PIG ILEAL LONGITUDINAL MUSCLES
- Taurine Prevents Oxidative Damage of High Glucose-Induced Cataractogenesis in Isolated Rat Lenses
- A NOTE ON WEAKLY PRIME IDEALS OF ORDERED SEMIGROUPS
- Hyperglycemic Response to Angiotensin II in Rabbits
- Synthesis of Copper Phthalocyanine-containing Hyperbranched Polymer Starting from 1,2-Bis(3,4-dicyanophenoxy)benzene and CuCl
- Complementarity for Strongly Coupled Coloron:Realization through Hidden Local Symmetry〔和文〕 (素粒子物理学の新展開)
- Levels of ATP in Different Areas of Contracting Rabbit Aorta under Aerobic Conditions
- Activity of Phosphofructokinase during Lactate Accumulation in Rabbit Aorta
- Levels of Glycogen Phosphorylase in Rabbit Aorta during a Prolonged Incubation
- Activities of Glycolytic Enzymes in Rabbit Aorta during Contraction
- Activity of Glycogen Phosphorylase in Rabbit Aorta during Contraction
- Glycolytic Enzymes in Rabbit Aorta and Iliac Artery
- Glycogen Phosphorylase in the Aorta and the Iliac Artery in Rabbits
- The Glycogenolytic Action of Angiotensin II
- EXPERIMENTAL ATHEROSCLEROSIS IN RATS FED A VITAMIN D, CHOLESTEROL-RICH DIET
- Toxicologic Investigation of Dimethylacrylamide in Mice
- FUNDAMENTAL STUDIES OF ANTHELMINTICS (XXII). ELECTROPHYSIOLOGICAL STUDIES OF 1-[2-(DODECYLOXY) ETHYL]PYRROLIDINE HYDROCHLORIDE (DEP) ON ASCARIS MUSCLE CELLS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- PJ-177 Enhanced expression of V-1, a novel catecholamine biosynthesis regulatory protein, in atrial myocytes of hypertrophic heart of Dahl hypertensive rats(Hypertension, Basic 2 (H) : PJ30)(Poster Session (Japanese))
- Electrical Properties of Self-Assembled Monolayers Using STM
- Reconsidering Composite Higgs Loop Effects in the Top Mode Standard Model : Particles and Fields
- Gluonic Phases and Phase Diagram in Neutral Two Flavor Dense QCD(Nuclear Physics)
- Theoretical and Experimental Analysis on the Thickness-Controlled Residual Stress during Drying of Solvent-Absorbed Polymer Films
- Maternal dietary n-6/n-3 fatty acid ratio affects type 1 diabetes development in the offspring of non-obese diabetic mice
- Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome
- Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases-Evidence From Basic to Clinical Studies : Preface
- Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases : Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer's Disease
- Effects of Functional Food Constituents on P-glycoprotein Activity in Caco-2 Cells Determined by a New Method Using Confocal Laser Scanning Microscopy
- Effects of Short-term Ginkgo Biloba Extract Feeding on Hypotensive Action of Nicardipine in Rats
- Effects of ATP on the Intracellular Calcium Level in the Osteoblastic TBR31-2 Cell Line
- Effects of Cholesterol Loading on Autoimmune MRL-lpr/lpr Mice. Susceptibility to Hypercholesterolemia and Aortic Cholesterol Deposition.
- Pharmacological Analysis of Receptors Involved in the Late, Tachykininergic Contractile Response to Electrical Transmural Stimulation in Isolated Rabbit Iris Sphincter Muscle.
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Hyperlipidemic effects of adriamycin in rats.
- Suppression of adjuvant arthritis in rats by cholesterol.
- Abnormal lipid metabolism in adjuvant arthritic rats.
- Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.
- Cholesterol reduces and corticosteroids enhance the toxicity of vitamin D in rats.
- Hypertensive Effects of Nitroarginine:Comparison between WKY and SHRSP
- P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
- A Uniform Alteration in Serum Lipid Metabolism Occurring during Inflammation in Mice.
- Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia.
- Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
- Impairment of Endothelium-Dependent Relaxation in Aorta from Rats with Arteriosclerosis Induced by Excess Vitamin D and a High-Cholesterol Diet.
- Altered Vasoconstrictor Responsiveness in Vitamin D-Induced Arteriosclerotic Rat Aortas.
- Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with .BETA.-aminopropionitrile: Effects of various anti-atherosclerotic agents on the biochemical parameters.