Pharmacological Analysis of Receptors Involved in the Late, Tachykininergic Contractile Response to Electrical Transmural Stimulation in Isolated Rabbit Iris Sphincter Muscle.
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概要
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We characterized the pharmacological nature of the tachykinin receptor subtype mediating the contractile response to electrical transmural stimulation (ETS) in the isolated rabbit iris sphincter muscle preparation by using selective NK<SUB>1</SUB>-receptor antagonists, spantide and L-668, 169, and a selective NK<SUB>2</SUB>-receptor antagonist, L-659, 877. ETS caused a biphasic contraction in this preparation: a rapidly developing cholinergic component followed by a slowly decaying tachykininergic component. The tachykininergic contractile response to ETS was effectively attenuated by spantide and L-668, 169, but only slightly by L-659, 877, indicating that the tachykinin receptors mediating ETS-induced contraction are of the NK<SUB>1</SUB> type. In the same preparation, the contractile activity of substance P (SP) was slightly more potent than that of neurokinin A (NKA). Unlike in other tissues rich in NK<SUB>1</SUB>-receptor subtypes, spantide and L-668, 169 antagonized the contractile response to NKA more effectively than that to SP, and the reverse was observed for L-659, 877. These results strongly suggest that the tachykininergic contraction induced by ETS in the rabbit iris sphincter preparation is mediated by NK<SUB>1</SUB>-receptors which are activated by endogenously released NKA.
- 公益社団法人 日本薬理学会の論文
著者
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Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Imaizumi Noriko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women''s University
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Sameshima Emiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women''s University
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Sameshima Emiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women''s University
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