Effects of nicotine on gastric contractile response to stimulation of the vagal afferent fibers in cats.
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概要
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Effects of nicotine on the delayed gastric contraction due to vagal afferent stimulation were studied. Cats were pretreated with phentolamine (2 mg/kg, i.v.) and propranolol (1 mg/kg, i.v.). The delayed contraction was inhibited by nicotine (100 to 2000 μg/kg, i.v.) in a dose-dependent manner. The inhibition of the delayed contraction by nicotine was blocked by hexamethonium (20 mg/kg, i.v.). The results suggested that nicotine inhibits the delayed contraction by activation of hexamethonium-sensitive inhibitory neurons in the vagal pathway to the stomach.
- 公益社団法人 日本薬理学会の論文
著者
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Okamoto Toshihiro
Department of Advanced Electron Devices, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki, Osaka 567-0047, Japan
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OKAMOTO Toshihiro
Department of Pharmacology, Faculty of Medicine
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KURAHASHI Kazuyoshi
Radioisotope Research Center, Kyoto University
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OKIKAWA Hiroshi
Aburahi Laboratories, Shionogi & Co., Ltd.
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OKIKAWA Hiroshi
Aburahi Laboratories, Shionogi & Co., Ltd.
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