Nitroglycerin-sensitive and -resistant contractions mediated by receptor-operated calcium channels in rabbit ear artery.
スポンサーリンク
概要
- 論文の詳細を見る
In isolated rabbit ear arteries incubated in a Ca<SUP>2+</SUP>-free medium with EGTA and nifedipine in the presence of norepinephrine, serotonin or histamine, an addition of Ca<SUP>2+</SUP> induced a tonic contraction which is due to Ca<SUP>2+</SUP> entry through receptor-operated Ca<SUP>2+</SUP> channels (ROCs). Nitroglycerin (10<SUP>-4</SUP> M) significantly inhibited the ROCs-dependent contractions produced by serotonin or histamine, but failed to inhibit the ROCs-dependent contraction by norepinephrine. These results suggest the possible existence of two types of receptor-operated Ca<SUP>2+</SUP> channels in rabbit ear artery.
著者
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Shibata Shoji
Department Of Pharmacology School Of Medicine University Of Hawaii
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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USUI Hachiro
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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KURAHASHI Kazuyoshi
Department of Pharmacology, Faculty of Medicine, and Radioisotope Research Center
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AKIMOTO Yoshinobu
Department of Pharmacology, Faculty of Medicine, Kyoto University
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