Cerebrovascular reactivities to N-methylated catecholamines in humans, monkeys and dogs.
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概要
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A comparison was made of the cerebrovascular responses of humans, monkeys and dogs to noradrenaline (NAd) and dopamine (DA) as well as to their N-methylated derivatives, adrenaline (Ad) and N-methyl dopamine (methyl DA). The present experiments demonstrated that N-methylation of both NAd and DA enhanced the contractile responses of these agents in human cerebral arteries, while only N-methylation of DA enhanced the contraction of monkey cerebral arteries, and such an enhancement was not seen in dog cerebral arteries.
- 公益社団法人 日本薬理学会の論文
著者
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Kurahashi Kazuyoshi
Pharmacology Division Radioisotope Research Center And Department Of Pharmacology Faculty Of Medicin
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USUI Hachiro
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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SHIRAHASE Hiroaki
Department of Pharmacology, Faculty of Medicine, Kyoto University
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