Effects of nitroglycerin on stable thromboxane A2 analogue-induced, nifedipine-resistant contraction in canine basilar artery.
スポンサーリンク
概要
- 論文の詳細を見る
The stable thromboxane A<SUB>2</SUB> analogue, STA<SUB>2</SUB>, caused concentrationdependent contractions in the canine basilar artery. In Ca<SUP>2+</SUP>-free medium containing EGTA (0.1 mM) and nifedipine (10<SUP>-6</SUP> M), the addition of Ca<SUP>2+</SUP> (2.5 mM) in the presence of STA<SUB>2</SUB> (10<SUP>-8</SUP> M) caused a tonic contraction (nifedipine-resistant Ca<SUP>2+</SUP>-induced contraction). In the basilar artery, nitroglycerin did not significantly affect such nifedipine-resistant Ca<SUP>2+</SUP>-induced contractions, but nearly abolished the contraction in the coronary artery. The present experiments suggest that the regulatory mechanism of mobilized Ca<SUP>2+</SUP> for the nifedipine-resistant Ca<SUP>2+</SUP>-induced contraction produced by STA<SUB>2</SUB> in the basilar artery is different from that in the coronary artery.
- 公益社団法人 日本薬理学会の論文
著者
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Shibata Shoji
Department Of Pharmacology School Of Medicine University Of Hawaii
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Suzuki Aritomo
Department Of Parasitology And Department Of Pharmacology
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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USUI Hachiro
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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KURAHASHI Kazuyoshi
Radioisotope Research Center, Kyoto University
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SHIRAHASE Hiroaki
Department of Pharmacology, Faculty of Medicine, Kyoto University
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AKIMOTO Yoshinobu
Department of Pharmacology, Faculty of Medicine, Kyoto University
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