<Review>A review on the properties and applications of perfluorocarbon emulsions
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概要
- 論文の詳細を見る
Besides modified hemoglobin solutions, the other main group of preparations competing in the field of blood substitutes are synthetic perfluorochemical emulsions (PFC). Their ability to transport oxygen has proven to be successful by the virtually complete blood substitution of rats with FC-43 preparation. Following comprehensive and profound experimental trials with another emulsion, Fluosol-DA 20% (FDA), the next breakthrough came with clinical application. FDA was used in the treatment of acute anemia, cases of ischemia and hypoxia including that of the brain, PTCA, in the perfusion of transplantation organs, and others. Many of the adverse reactions caused by FDA 20% were found to result from complement activation provoked by the emulsifier, Pluoronic F-68. The latest generation PFC emulsions are designed to be more safe and efficient. The application of some PFC preparations in diagnostics looks very promising.
- 近畿大学の論文
著者
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Higashino Hideaki
Department of Pharmacology, Kinki University School of Medicine
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Higashino Hideaki
Department Of Pharmacology Kinki University School Of Medicine
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SUZUKI Aritomo
Department og Pharmacology, Kinki University School of Medicine
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MEGA Noriko
Department of Pharmacology, Kinki University School of Medicine
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Mega N
Kinki Univ. School Of Medicine Osaka Jpn
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Mega Noriko
Department Of Anesthesiology Kinki University School Of Medicine
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Suzuki Aritomo
Department Of Parasitology And Department Of Pharmacology
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VOYNIKOV Tencho
Department of Pharmacology, Kinki University School of Medicine
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NIKOLOVA Irina
Department of Pharmacology, Kinki University School of Medicine
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PETKOVA Maria
Department of Pathophysiology, Medical Academy
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Nikolova Irina
Department Of Pharmacology Kinki University School Of Medicine
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Petkova Maria
Department Of Pathophysiology Medical Academy
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Voynikov Tencho
Department Of Pharmacology Kinki University School Of Medicine
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Higashino Hideaki
Department Of Pharmacology Kinki University Faculty Of Medicine
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