Relaxant Effects of Calcitonin Gene-related Peptide on Isolated Small Renal Arteries in Stroke-Prone Spontaneously Hypertensive Rats.
スポンサーリンク
概要
- 論文の詳細を見る
The relaxant effects of calcitonin gene-related peptide (CGRP) on the 3rd branches of renal arteries obtained from stroke-prone spontaneously hypertensive rats (SHRSP), and Wistar-Kyoto rats (WKY) were investigated in vitro. CGRP elicited concentration-dependent relaxation, and the relaxant response was not affected by the mechanical removal of endothelium in either SHRSP or WKY. The CGRP-induced relaxant response was markedly greater in SHRSP than in WKY, whereas there was no significant difference in acetylcholine-induced relaxation, which was endothelium-dependent, between the two groups. Additionally, significantly enhanced reactivity to CGRP was also shown in sponta-neously hypertensive rats compared to WKY; however, this reactivity was less than that observed in SHRSP.There were also no significant differences between WKY and SHRSP in the relaxation induced by forskolin, dibutyryl cyclic AMP, and 3-isobutyl-1-methylxanthine (IBMX). CGRP-induced relaxation was significantly potentiated in similar manner by the pretreatment with IBMX in both WKY and SHRSP.Incubation with glibenclamide (10<SUP>-6</SUP> M) had no effect on CGRP-induced relaxation in either group, the WKY or the SHRSP. These results suggest that CGRP produces endothelium-independent relaxation in the small renal arteries in the rat, and that the increased CGRP-induced relaxant response found in SHRSP may not be associated with the altered vasodilation mediated by cyclic AMP, or with functional changes in ATP-sensitive potassium channels.
- 日本平滑筋学会の論文
著者
-
Suzuki Aritomo
Department Of Parasitology And Department Of Pharmacology
-
Yoshida Kazumi
Department Of Immunology And Immunotherapy Kurume University School Of Medicine
-
GAO Yujing
Department of Pharmacology, Kinki University School of Medicine
-
Gao Yujing
Department Of Pharmacology Kinki University School Of Medicine
-
NISHIMURA Yoshitaka
Department of Environmental and Materials Engineering, Nagoya Institute of Technology
関連論文
- Reactivity of Intrarenal Arteries to Vasoconstrictor and Vasorelaxant Polypeptides in Adult Stroke-Prone Spontaneously Hypertensive Rats
- Endothelin participates in a process of fibrinogen-involved platelet aggregation
- Upper shift of the set point in the thermocenter causes hyperthermia in SHRSP
- Inhibitory effects of traditional crude drug extracts on the nasal allergy induced by ovalbumin in the guinea pig
- Thermo-elevation effect on blood flow in stroke-prone spontaneously hypertensive rats (SHRSP)
- Characterization of dopamine-induced vasorelaxation in isolated renal arteries from stroke-prone spontaneously hypertensive rats
- Influence of L-NNA and GTN on blood pressure and heart rate in conscious SHRSP and WKY
- Influence of endothelin-1 on systolic arterial pressure and heart rate in conscious WKY and SHRSP
- A trial of chronic administration of Siamese Momordica charantia and Phyllanthus urinaria powders to streptozotocin-induced diabetic rats
- Age-related changes in serum and tissue angiotensin converting enzyme activities in SHRSP and WKY
- Effects of Isoteoline on the blood pressure and renin-angiotensin system in spontaneously hypertensive rats
- Influence of Nivalin P on the training and memorizing processes in rats
- Pharmacological and toxicological study of newly synthesized 1,3-dimethylxanthine derivatives
- The responses to various relaxing substances in the renal arteries and the aortas of stroke-prone spontaneously hypertensive rats (SHRSP) at various ages
- Morphological and Cytoskeletal Changes in Endothelial Cells of Vein Grafts under Arterial Hemodynamic Conditions In Vivo
- Effects of Sodium Nitrite on the Contractions in the Vas Deferens from Guinea Pig
- Effects of Methylene Blue and Acridine Orange on the Contraction in the Vas Deferens from Guinea Pig
- Effects of pH and Temperature on Drug-Induced Contractions in the Isolated Guinea Pig Vas Deferens
- Effects of Local Anesthetics on the Responses to Some Contractile Agents, Especially in Relation to Ca
- A Possible Mechanism for Cadmium-Induced Hypertension in Rats
- Relaxation responses to various drugs in blood vessels of malignant stroke-prone spontaneously hypertensive rats (M-SHRSP)
- A review on the properties and applications of perfluorocarbon emulsions
- A CALCIUM ANTAGONIST, NB-818, IMPROVES BLOOD FLOW DISTRIBUTION IN THE BRAIN AND OTHER MAJOR ORGANS OF STROKEPRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP)
- The Relaxation Mechanism of Papaverine and Aminophylline in Vas Deferens of Guinea Pig, Particularly in Relation to Ca
- Effect of endothelins on the fibrinogen-involved aggregation process in platelets of guinea pig
- Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different human leukocyte antigen-class I-A alleles
- A POSSIBLE MECHANISM OF INFERTILITY BY ACUTE CADMIUM INTOXICATION
- EFFECTS OF CADMIUM ON THE TENSION OF ISOLATED RAT AORTA (A POSSIBLE MECHANISM FOR CADMIUM-INDUCED HYPERTENSION)
- Diabetic Retinopathy and α_2-Macroglobulin
- Contractile Mechanism of ATP in Isolated Vas Deferens of Guinea Pigs
- Pharmacological investigation of peptide-induced vasorelaxation in the isolated intrarenal arteries of stroke-prone spontaneously hypertensive rats
- Impairment of Passive Avoidance Performance in SART-Stressed Mice and the Action of Drugs
- The Abnormal Open-Field Behavior of SART-Stressed Rats and Effects of Some Drugs on It
- Changes in Platelet Count and Related Parameters in SART-Stressed Mice and the Action of Administered Neurotropin
- Changes of Tissue Blood Flow in Mice Loaded with SART (Repeated Cold) Stress or Restraint and Water Immersion Stress and the Effect of Administered Neurotropin
- Responses to seven vasorelaxant neuropeptides in small renal arteries isolated from stroke prone spontaneously hypertensive rats
- Inhibitory Effect of Chlorpromazine on the Myocardial Contractility
- Comparative Studies on Inhibition of the K-Induced Tonic Contraction in Guinea Pig Vas Deferens by Chlorpromazine, Zotepine and their Free Radicals
- Mechanism of the Contracting Actions of K, Acetylcholine, Histamine, Noradrenaline and Ba in the Excised Vas Deferens of Guinea Pig, Particularly in Relation to Ca
- Effects of cholecalciferol and calcium on experimental hepatic osteodystrophy in rats
- The Contractile Mechanism of Acetylcholine in the Isolated Seminal Vesicle of Guinea Pig, Particulary as to the Catecholamine Release
- Dielectric breakdown and thermal conductivity of textured alumina from platelets
- Relaxation responses to various drugs in tail arteries from stroke-prone spontaneously hypertensive rats, especially in relation to aging
- Norepinephrine Sensitivity, Reactivty and Neuronal Uptake in the Isolated Vas Deferens from SHRSP and WKY
- Influence of Ca Contents in the Medium on the Responses to the Smooth Muscle Contractile Agents in the Isolated Vas Deferens from SHRSP
- The Modification of the Responses to Noradrenaline and Acetylcholine by Aging and the Effects of Some Smooth Muscle Relaxants on the Smooth Muscle Contractile Drugs:Experiment in the Isolated vas Deferens of SHRSP and Wistar-Kyoto Rats
- Microstructures and Photovoltaic Properties of Polysilane-Based Solar Cells
- Synthesis and Metabolism of Dopamine in Kidney Slices of Stroke-Prone Spontaneously Hypertensive Rats
- A characteristic pattern of active avoidance behavior in SART-stressed rats.
- On the Hypotensive Flavonoids in Young Barley Leaves (Part 2). Di-C-gluco-sylflavone
- On the Hypotensive Substances in Chlorella Extract
- On the Hypotensive Substances of Bamboo Leaves
- Effects of vasodilators on the tonus of aortas from SHRSP and WKY, especially in relation to aging
- The enhanced effects of adrenaline and serotonin on ADPinduced platelet aggregation in SHRSP
- A Study on the Hyperthermia in SHRSP; a Comparison with WKY in Body Temperature (the Second Report)
- Comparison of Platelet Aggregation Activities between SHRSP and WKY, with Special Reference to Aging
- Measurements of Intracellular Free Calcium Levels in Platelets of SHRSP and WKY and Possible Relation to Its Aggregation Potency
- Spare receptor in the isolated blood vessels from SHRSP
- Abnormal responses to the vasoconstrictor sgents in isolated aortas from SHRSP, especially in relation to aging
- Spare Receptors in Aortas from Stroke-Prone SHR and WKY
- Hypertensive Mechanism of Cadmium (Experiment in The isolated Aorta from SHRSP)
- Electrocorticogram in rats loaded with SART stress (repeated cold stress).
- Comparative Studies on the Structure of Extracellular Matrix in Aortic Walls of SHRSP and WKY
- The relaxation responses of superior mesenteric arteries of SHRSP, with special references to aging
- Effect of Ca2+ Contents in Medium on the Responses to Some Contractile Agents in Isolated Portal Veins from SHRSP and WKY
- Antihypertensive and Other Pharmacological Effects of the Calcium Antagonist, NB-818, in 2- and 6-month-old SHRSP
- Effects of Some Spasmolytics on The Responses to The Smooth Muscle Contractile Agents:Experiment in The Isolated Portal Vein from SHRSP
- On the Hypotensive Substances in Plants:(2) Fractionation of Plant Extracts and Mechanism of Their Action
- Changes in Ca-ATPase Activity and Ca Uptake Rate of Heart Muscle SR of the Stroke-Prone SHR in Relation to Aging
- Reactivity to receptor and Ca2+ availability in vascular smooth muscle from SHRSP
- 2, 3 diphosphoglycerate (2, 3DPG) values in stroke-prone spontaneously hypertensive rats (SHRSP):Its relationship to aging
- Responses of isolated renal arteries in SHRSP to vasodilators and transmural electrical stimulation
- Cerebral Arterial Disorder in SHRSP:The Determination of Cells and Various Connective Tissues
- Comparison of the Direct and Indirect Measurements for Blood Pressure and Heart Rate in Relation to the External Temperature in 12-month-old SHRSP and WKY
- Effect of Hypoxia on the Physiological States of SHRSP and WKY
- Response to Vasoactive Neuropeptides in Basilar Arteries Isolated from Stroke-Prone Spontaneously Hypertensive Rats
- Responses to noradrenaline, phenylephrine and clonidine in the vascular smooth muscle of SHRSP
- 2, 3Diphosphoglycerate (2, 3DPG) Production-degradation Systems in SHRSP and WKY
- Depressor and pressor effects of endothelin-1 and endothelin-3 in conscious WKY and SHRSP
- Vasorelaxation Response of Basilar Arteries Isolated from Stroke-Prone Spontaneously Hypertensive Rats
- Hypotensive Effects of the Siamese Plants on SHRSP:Imperata Cylindrica and Phyllanthus Emblica Extracts
- Relaxant Effects of Calcitonin Gene-related Peptide on Isolated Small Renal Arteries in Stroke-Prone Spontaneously Hypertensive Rats.
- Alpha-1 Adrenergic Function in Hemodynamic Control of Stroke-prone Spontaneously Hypertensive Rats (SHRSP)
- Effects of Calcium Antagonist, NB-818, on the Regional Hemodynamics in Conscious 6-month-old SHRSP and WKY
- The Effect of ONO-3144 on the Prolongation of Life-Span in SHRSP
- Effect of cadmium ions on the tension of isolated vascular smooth muscles from SHRSP
- Effects of L-NNA and GTN on blood pressure and heart rate in conscious SHRSP and WKY
- Effects of nitroglycerin on stable thromboxane A2 analogue-induced, nifedipine-resistant contraction in canine basilar artery.
- Age-related Changes in Platelet Aggregation Activity and Some Drug Modification on Platelet Function
- Altered Relaxation of the Isolated Aortas in Aging and Hypertension
- The Reactivity of Vascular Smooth Muscle in Stroke-Prone SHR, especially from the Standpoint of Aging
- Effects of Cadmium in the Isolated Vascular Smooth Muscle from WKY and SHRSP
- NORADRENALINE-INDUCED BIPHASIC RESPONSES IN PULMONARY ARTERIES OF YOUNG STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS:ROLE OF ENDOTHELIUM
- The Changes in Angiotensin Converting Enzyme Activities to Hypertension in SHRSP and WKY
- Relaxant Response of Isolated Basilar Arteries to Calcitonin Gene-Related Peptide in Stroke-Prone Spontaneously Hypertensive Rats.