<Originals>Influence of Nivalin P on the training and memorizing processes in rats

概要

論文の詳細を見る
The effects of Nivalin P-in a combination ratio of 1 : 1 by two compounds Galan-thamine (Nivalin) and 4-aminopyridine (Pymadin) on the total latency time, conditional, unconditional and inadequate reactions in rats were studied. Nivalin is a cholinesterase inhibitor which enhances the cholinergic system by blocking the degradation of the mediator acetylcholine (ACh) in the synapse. Pymadin is a stimulator of the presynaptic release of ACh and its synthesis. The experiments were performed with male Wistar rats weighing 150-170g which were divided into 4 groups : control and three experimental groups treated orally with Nivalin P in a dose of 6.6 mg/kg (=1/5 LD_<50>), 3.3 mg/kg (= 1/10 LD_<50>) and 1.65 mg/kg (= 1/20 LD_<50>), respectively. A two-way active avoidance method in a "shuttle box" and the method of Valcelli, L. were used for examination of the memory traces. Nivalin P applied in a dose 1/20 of the LD_<50> orally in rats facilitates the training of rats and improves the memory capabilities decreasing the number of inadequate replies. These findings indicate that Nivalin P in low doses induces the enhancement of the cholinergic activity by pharmacological intervention within the synapse. Apparently, the role of combination therapies, including inhibitors of the breakdown of ACh with facilitators of neuronal calcium uptake appears logical and might be useful in the treatment of Alzheimer's disease.
近畿大学の論文