<Therapy>Effects of Isoteoline on the blood pressure and renin-angiotensin system in spontaneously hypertensive rats
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概要
- 論文の詳細を見る
The effects of Isoteoline (IST), a new tetrahydroaporphine derivative, on the blood pressure and renin-angiotensin-aldosterone system (RAAS) in spontaneously hypertensive rats (SHR) were studied. The experiments were performed with adult (8 months of age) male SHR of the Okamato-Aoki strain, generation F^<26>-F^<37> weighing 250±10g. Systolic blood pressure was measured indirectly in conscious restrained rats by tail-cuff plethysmography with sphygmomanometer. Plasma renin activity, angiotensin II and aldosterone plasma levels were determined by radio-immunoassay. The angiotensin converting enzyme (ACE) activity in vivo and in vitro was estimated by a modified fluorometric assay, while changes in the electrolyte levels in plasma(Na^+, K^+ and Cl^-) were determined by flame photometry. It was established that IST administered in doses of 1 and 5 mg/kg orally and intraperitoneally after single (6 days) and long-term(14 days 3 times daily) treatment decreased the systolic blood pressure and levels of the components of RAAS. The results suggest that the effects of IST on SHR was most probably realized through an influence on the adrenergic and dopaminergic mediatory systems.
- 近畿大学の論文
- 1994-12-30
著者
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Higashino Hideaki
Department of Pharmacology, Kinki University School of Medicine
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Higashino H
Kinki Univ. School Of Medicine Osaka Jpn
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Higashino Hideaki
Department Of Pharmacology Kinki University School Of Medicine
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SUZUKI Aritomo
Department og Pharmacology, Kinki University School of Medicine
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MARKOV Marko
Department of Pharmacology, Faculty of Medicine, Higher Medical School
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Suzuki A
Kinki Univ. School Of Medicine Osaka Jpn
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Markov Marko
Department Of Pharmacology Faculty Of Medicine Higher Medical School
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Suzuki Aritomo
Department Of Parasitology And Department Of Pharmacology
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Higashino Hideaki
Department Of Pharmacology Kinki University Faculty Of Medicine
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