<血行動態に関する研究>Responses to seven vasorelaxant neuropeptides in small renal arteries isolated from stroke prone spontaneously hypertensive rats
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概要
- 論文の詳細を見る
Relaxation responses to seven vasodilator neuropeptides were examined in 3rd order branches of renal arteries isolated from 6-7-month-old SHRSP and age-matched WKY. Calcitonin generelated peptide (CGRP) induced markedly increased endothelium-independent relaxation in SHRSP rats compared to that in WKY rats. Relaxations generated by atrial natriuretic peptide, brain natriuretic peptide, vasoactive intestinal peptide, peptide histidine isoleucine were all endothelium-independent, while bradykinin-induced relaxation was dependent on the presence of an intact endothelium. There were no significant differences between specimens from SHRSP and WKY in their relaxations. Substance P caused almost no relaxation in these arteries. Thus, enhanced reactivity to CGRP appears to be a specific change in SHRSP.
- 近畿大学の論文
- 1994-12-30
著者
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Nakai Yoshihiro
Department of Cardiology, Komatsushima Red Cross Hospital
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NISHIMURA Yoshitaka
Department og Pharmacology, Kinki University School of Medicine
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Suzuki Aritomo
Department Of Parasitology And Department Of Pharmacology
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GAO Yujing
Department of Pharmacology, Kinki University School of Medicine
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KOH Tosei
Department of Pharmacology, Kinki University School of Medicine
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Koh Tosei
Department Of Pharmacology Kinki University School Of Medicine
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Gao Yujing
Department Of Pharmacology Kinki University School Of Medicine
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Nishimura Yoshitaka
Department Of Pharmacology Kinki University School Of Medicine
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NISHIMURA Yoshitaka
Department of Environmental and Materials Engineering, Nagoya Institute of Technology
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