<Originals>Relaxation responses to various drugs in tail arteries from stroke-prone spontaneously hypertensive rats, especially in relation to aging
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概要
- 論文の詳細を見る
It has been reported that the spontaneously hypertensive rat (SHR) is a useful animal model for the study of human essentilal hypertension. It is generally accepted that blood vessel tone depends on the contractile and relaxation responses. Thus, a reduced relaxation response might induce elevated blood pressure. Rat tail is an important organ for the body balance and heat radiation. There are very few reports concerning the effects of blood pressure on the responses to the relaxants in the tail artery. In the present study, the relaxation responses of taii arteries from stroke-prone SHR (SHRSP) and Wistar-Kyoto rats (WKY) were investigated from the standpoint of aging. Some of experimental results were compared to those of the aorta : Relaxation responses to acetylcholine (ACh) and histamine, endothelium-derived relaxing factors decreased with age in both SHRSP and WKY tail arteries, with SHRSP exhibiting lower values. The same results were obtained in SHRSP and WKY aortas. The relaxation responses to ACh and histamine in the tail artery were less than in the aorta. Examination of the relaxation responses to nitroprusside and nitroglycerin revealed that NO radical-containing drugs did not alter with age in both SHRSP and WKY tail arteris, and were not different between SHRSP and WKY tail arteries. The same results were obtained in SHRSP and WKY aortas. The relaxation responses to nitroprusside in tail arteries were somewhat less than those in aorta. The relaxation response to isoproterenol (Iso), a β-receptor stimulating drug decreased with age in both SHRSP and WKY tail arteries, but to a great degree among SHRSP. The relaxation responses to Iso almost disappeared in 6-month-old SHRSP. The effects of forskolin and dibutyryl cAMP did not change with age in both SHRSP and WKY tail arteries. Also, the relaxation responses to those drugs were not different between SHRSP and WKY. The relaxation responses to diltiazem, a Ca^<2+> antagonist, in tail arteries were reduced in WKY, not in SHRSP.
- 近畿大学の論文
著者
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Nishimura Yoshitaka
Department Of Pharmacology Kinki University School Of Medicine
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Yamanishi Yasuko
Department Of Pharmacology Kinki University School Of Medicine
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NISHIMURA Yoshitaka
Department of Environmental and Materials Engineering, Nagoya Institute of Technology
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NISHIMURA Yoshitaka
Department of Pharmacology, Kinki University School of Medicine
関連論文
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- The Abnormal Open-Field Behavior of SART-Stressed Rats and Effects of Some Drugs on It
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- Changes of Tissue Blood Flow in Mice Loaded with SART (Repeated Cold) Stress or Restraint and Water Immersion Stress and the Effect of Administered Neurotropin
- Responses to seven vasorelaxant neuropeptides in small renal arteries isolated from stroke prone spontaneously hypertensive rats
- Dielectric breakdown and thermal conductivity of textured alumina from platelets
- Relaxation responses to various drugs in tail arteries from stroke-prone spontaneously hypertensive rats, especially in relation to aging
- Responses to vasocontractile agents in caudal artery and aorta from stroke-prone SHR, especially in relation to aging
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- Antihypertensive and Other Pharmacological Effects of the Calcium Antagonist, NB-818, in 2- and 6-month-old SHRSP
- Response to Vasoactive Neuropeptides in Basilar Arteries Isolated from Stroke-Prone Spontaneously Hypertensive Rats
- Vasorelaxation Response of Basilar Arteries Isolated from Stroke-Prone Spontaneously Hypertensive Rats
- Relaxant Effects of Calcitonin Gene-related Peptide on Isolated Small Renal Arteries in Stroke-Prone Spontaneously Hypertensive Rats.
- NORADRENALINE-INDUCED BIPHASIC RESPONSES IN PULMONARY ARTERIES OF YOUNG STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS:ROLE OF ENDOTHELIUM
- Relaxant Response of Isolated Basilar Arteries to Calcitonin Gene-Related Peptide in Stroke-Prone Spontaneously Hypertensive Rats.