EFFECTS OF CDP-CHOLINE ON STRIATAL DOPAMINE LEVEL AND BEHAVIOR IN RATS
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概要
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To further assess the effects of CDP (cytidine diphosphate)-choline on Parkinsonian symptoms, striatal dopamine (DA) was measured fluorometrically in rats after injection of CDP-choline. CDP-choline (300 mg/kg, i.p.) increased the DA content in the striatum (p<0.05) one hour after injection. The behavioral effect of CDP-choline was then tested in rats in which the unilateral nigro-striatal DA neurons had degenerated following an intranigral injection of 6-hydroxydopamine (6-OHDA). CDP-choline alone did not produce behavioral changes in these rats. However, pretreatment with a single dose of CDP-choline (900 mg/kg, i.p.) suppressed both the apomorphine-induced contralateral and the d-amphetamine-induced ipsilateral circling. The same dose of CDP-choline suppressed the number of treadmill revolutions in mice. On the other hand, a 7-day consecutive treatment with 300 mg/kg of CDP-choline enhanced the apomorphine-induced contralateral circling (by 42%, p<0.05). The same treatment with CDP-choline raised the striatal DA content by 29% (p<0.05) on the intact side, but not on the 6-OHDA injected side.These results indicate that CDP-choline has neither a direct nor an indirect DA agonistic effect. The increase in DA content, decrease in locomotion and enhancement of the effect of apomorphine can be explained on the hypothesis that CDP-choline may act as an antagonist on the DA neurons and receptors. The validity of this apparently paradoxical use of CDP-choline with antagonistic effect on DA neurons in the treatment of Parkinsons disease is descussed.
- 社団法人 日本薬理学会の論文
著者
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Taniguchi Takashi
Department of Geophysics, Faculty of Science, Hokkaido University
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Shibuya Masato
Department Of Neurosurgery Chukyo Hospital
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KAGEYAMA Naoki
Department of Neurosurgery, Nagoya University school of Medicine
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HIDAKA Hiroyoshi
Department of Pharmacology,Nagoya University School of Medicine
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Kageyama Naoki
Department Of Neurosurgery Kishiwada City Hospital
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FUJIWARA Motohatsu
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Taniguchi Takashi
Department Of Geophysics Faculty Of Science Hokkaido University
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Fujiwara Motohatsu
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Hidaka Hiroyoshi
Department Of Pharmacology Mie University
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Shibuya Masato
Department Of Forest Science Faculty Of Agriculture Hokkaido University
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Taniguchi Takashi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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HIDAKA Hiroyoshi
Department of Biochemistry, Institute for Developmental Research, Aichi Prefecture Colony
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TANIGUCHI Takashi
Department of Computational Science and Engineering, Nagoya University
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SHIBUYA Masato
Department of Neurosurgery, Nagoya University School of Medicine
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Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
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