MODIFICATION BY AZ-55, GUANETHIDINE AND BRETYLIUM OF RESPONSES OF ATRIA AND AORTIC STRIPS TO TRANSMURAL STIMULATION
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概要
- 論文の詳細を見る
A new antihypertensive drug (1), 1-cyclohexyl-3-guanidinoazetidine sulfate (AZ-55), structurally resembles guanethidine. It is widely known that guanethidine depresses peripheral adrenergic nerve function by preventing release of adrenergic nerve transmitters (reviewed by Boura and Green, 2). Bretylium also possesses the adrenergic neuron blocking action, but accumulated data point to the fact that bretylium and guanethidine fail to share all mechanisms of the blocking action (2).<BR> The present study was aimed to investigate the effects of AZ-55 on responses of S-A nodes of the heart and of aortic smooth muscles to transmural neural stimulation, tyramine and noradrenaline. Effects were then compared with those of guanethidine and bretylium.
- 社団法人 日本薬理学会の論文
著者
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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USUI Hachiro
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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SHIMAMOTO Kiro
Department of Pharmacology, Faculty of Medicine, Kyoto University
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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USUI Hachiro
Department of Pharmacology, Faculty of Medicine, Kyoto University
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USUI Hachiro
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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SHIMAMOTO KIRO
Department of Pharmacology, Faculty of Medicine, Kvoto University
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