Inhibition of Dog Renin Activity by Pepstatin A : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
- 論文の詳細を見る
The inhibitory effect of pepstatin A, an isovaleryl pentapeptide isolated from streptmyces, was studied. Pepstatin A inhibited the action of dog renin on homologus substrate. The Ki value was 7.7 × 10^<-7>M and the mode of the inhibition was non-competitive. Pestatin A suppressed angiotensin I generation in dog plasma. Dose-dependent hypotensive effect of pepstatin A was observed in rats with sustained increase in blood pressure during continuous infusion of dog renin. It is concluded that pepstatin A inhibits the dog renin activity in vitro and in vivo.
- 社団法人日本循環器学会の論文
- 1979-10-20
著者
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MIYAZAKI Mizuo
Department of Pharmacology, Osaka Medical College
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Miyazaki Mizuo
Department Of Pharmacology Shiga University Of Medical Sciences
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Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
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Okunishi Hideki
Department of Pharmacology, Shimane Medical University
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Okunishi H
Shimane Medical Univ. Shimane Jpn
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Okunishi Hideki
Department Of Pharmacology Shiga University Of Medical Sciences
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Sciences
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KOMORI TADAMITSU
Department of Pharmacology, Osaka City University Medical School
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Komori Tadamitsu
Department Of Pharmacology Osaka City University Medical School
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Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
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Miyazaki Mizuo
Department Of Pharmacoldgy Osaka Medical College
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TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
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