Functional Studies on Blockade by Neosurugatoxin of Nicotinic Receptors in Nitroxidergic and Sensory Nerve Terminals and Intramural Ganglionic Cells
スポンサーリンク
概要
- 論文の詳細を見る
In isolated canine cerebral and cutaneous arteries and duodenum, effects of neosurugatoxin (NSTX) on the response to nicotine were compared. Nicotine-induced relaxations are mediated by nitric oxide (NO) from vasodilator nerves in cerebral arteries and by calcitonin gene-related peptide (CGRP) in cutaneous arteries treated with NO synthase inhibitors. Duodenal relaxation to nicotine is mediated by NO from inhibitory nerves. Cerebral arterial strips without endothelium responded to nicotine with relaxations that were inhibited by NSTX (3×10-10 to 3×10-9 M) concentration-dependently. Relaxations to nicotine of duodenal strips were attenuated by NSTX and abolished by tetrodotoxin, whereas those induced by K+ and electrical stimulation were not influenced. In cutaneous arteries treated with NG-nitro-L-arginine, nicotine-induced relaxations were attenuated by NSTX as low as 10-10 M, but unaffected by tetrodotoxin. The inhibitory potency of NSTX was in the order of cutaneous artery > duodenum > cerebral artery. It is concluded that NSTX selectively antagonizes actions on nicotinic receptors in nitroxidergic nerves of cerebral arteries, CGRP-mediated sensory nerves of cutaneous artery and ganglionic cells of the duodenum, but the affinity of this toxin to nicotinic receptors in sensory nerves is the highest.
- 社団法人 日本薬理学会の論文
- 1998-10-01
著者
-
Toda Noboru
Department of Pharmacology, Sniga University of Medical Sciences
-
OKAMURA Tomio
Department of Pharmacology, Shiga University of Medical Science
-
Okamura T
Department Of Pharmacology Shiga University Of Medical Science
-
NAKAYAMA Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical
-
AYAJIKI Kazuhide
Department of Pharmacology, Shiga University of Medical Science
-
TSUJI Kuniro
Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University o
-
Okamura Tomio
Department Of Pharmacology
-
Toda N
Department Of Pharmacology Shiga University Of Medical Science
-
Tsuji Kuniro
Department Of Pharmacology Shiga University Of Medical Science
-
Nakayama Koichi
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Iwate Medical U
-
Okamura T
Shiga Univ. Medical Sci. Ohtsu Jpn
-
FUJIOKA Hideyuki
the Department of Pharmacology, Shiga University of Medical Science
-
Toda Noboru
Department Of Pharmacology Shiga University Of Medical Science
-
FUJIOKA Hideyuki
Department of Pharmacology, Shiga University of Medical Science
-
Fujioka Hideyuki
Department Of Pharmacology Shiga University Of Medical Science
-
Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
-
Ayajiki Kazuhide
Department Of Pharmacology Shiga University Of Medical Science
-
Nakayama Koichi
Departments Of Pharmacology School Of Pharmaceutical Sciences University Of Shizuoka
-
Fujioka Hideyuki
Department Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Scien
-
Ayajiki Kazuhide
Department Of Pharmacy School Of Pharmacy Hyogo University Of Health Sciences
-
TODA Noboru
Department of f Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- Mechanism Underlying Endothelium-Dependent Relaxation by 2-Methylthio-ADP in Monkey Cerebral Artery
- Mechanisms Underlying Mechanical Responses to Ephedra herb of Isolated Rabbit Urinary Bladder and Urethra, a Possible Stress Urinary Incontinence Therapeutic
- -96-HYPOTENSIVE EFFECT OF A SPECIFIC INHIVITOR OF HUMAN RENIN
- Involvement of Cyclooxygenase-2 in Synergistic Effect of Cyclic Stretching and Eicosapentaenoic Acid on Adipocyte Differentiation
- Expression of Xeroderma Pigmentosum Group G (XPG) in Sporadic Breast Carcinoma
- Nitric Oxide-Mediated Neurogenic Relaxation in Monkey Mesenteric Veins
- Role of Na^+/Ca^ Exchanger-Mediated Ca^ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Mechanisms Underlying Endothelial Dysfunction in the Insulin-Resistant State
- Stress and Vascular Responses: Oxidative Stress and Endothelial Dysfunction in the Insulin-Resistant State
- Antagonistic Effect of N-Methyltyramine on α_2-Adrenoceptor in Mice
- Characterization of nitrergic function in monkey penile erection in vivo and in vitro
- (+)-[^3H] Isradipine and [^3H] Glyburide Bindings to Heart and Lung Membranes From Rats With Monocrotaline-Induced Pulmonary Hypertension
- Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries
- Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor
- LENGTH-PASSIVE TENSION RELATIONSHIPS IN CEREBRAL AND PERIPHERAL ARTERIES ISOLATED FROM SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS
- Inhibition of Dog Renin Activity by Pepstatin A : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Contractile Potentiation by Endothelin-1 Involves Protein Kinase C-δ Activity in the Porcine Coronary Artery
- Impedance Cardiography for the Assessment of Cardiac Function During Exercise : SYMPOSIUM ON EXERCISE TESTINGS OF HEART DISEASE
- Glibenclamide-Sensitive Hypotension Produced by Helodermin Assessed in the Rat
- Flow-Dependent Regulation of Nitric Oxide Formation in the Isolated Canine Mesenteric Arterial Bed
- Flow Regulates Vasodilator Responses to Acetylcholine in the Isolated Canine Mesenteric Arterial Bed
- Differential involvement of α_1-adrenoceptors in vasoconstrictor responses to cooling in mouse plantar arteries in vitro and in vivo
- Role of Na+/Ca2+ Exchanger–Mediated Ca2+ Entry in Pressure-Induced Myogenic Constriction in Rat Posterior Cerebral Arteries
- Distinct Roles of Protein Kinase C Isoforms in Myogenic Constriction of Rat Posterior Cerebral Arteries
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Preface
- Evidence for Protein Kinase C-Mediated Activation of Rho-Kinasein a Porcine Model of Coronary Artery Spasm
- ^Mg (d,p)^Mg Reactions at 3.1 and 3.5 MeV
- THE REGIONAL DIFFERENCES OF THE CONTRACTILE RESPONSE TO VASOACTIVE SUBSTANCES IN ISOLATED DOG CORONARY ARTERIES : Coronary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- Mediation of Arachidonic Acid Metabolite(s) Produced by Endothelial Cytochrome P-450 3A4 in Monkey Arterial Relaxation
- Involvement of Different Activator Ca^ in the Rate-Dependent Stretch-Induced Contractions of Canine Basilar Artery
- EFFECTS OF ELCATONIN ON PLASMA AND URINE ELECTROLYTES IN INFANT BEAGLES
- Facilitation of L-type Ca^ Currents by Fluid Flow in Rabbit Cerebral Artery Myocytes
- Functional Studies on Blockade by Neosurugatoxin of Nicotinic Receptors in Nitroxidergic and Sensory Nerve Terminals and Intramural Ganglionic Cells
- Inhibition by Adrenomedullin of the Adrenergic Neurogenic Response in Canine Mesenteric Arteries
- MODIFICATION BY CADMIUM IONS OF 45CALCIUM UPTAKE BY ISOLATED RABBIT AORTAE
- REGIONAL AND SPECIES DIFFERENCES IN THE RESPONSE OF ISOLATED ARTERIES TO ANGIOTENSIN II
- Nitric Oxide Synthase Activity in Human Thyroid Papillary Carcinomas
- INFLUENCE OF FENTANYL ON THE CHRONOTROPIC RESPONSE OF ISOLATED RABBIT ATRIA TO CHOLINERGIC AND ADRENERGIC STIMULATION
- RESPONSES OF ISOLATED DOG CORONARY ARTERIES TO TYRAMINE
- INTERACTIONS OF Cd++ AND CYSTEINE ON Ca++ CONTENT AND CONTRACTILITY OF ISOLATED AORTAS AND CARDIAC MUSCLES
- CONTRACTILE RESPONSES OF ISOLATED DOG MESENTERIC ARTERIES TO ANGIOTENSIN I, II AND III
- β_1-Adrenoceptor-Mediated Relaxation by Norepinephrine in Dog Hepatic Arteries
- Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide
- Protection by Hypothermia of Hypoxia-Induced Ingibition of Neurogenin Vasodilation in Porcine Cerebral Arteries
- Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins
- Neurogenic Cerebral Vasodilation Mediated by Nitric Oxide
- Effects of Calcium Antagonists on the Nitrergic Nerve Function in Canine Corpus Cavernosum
- Hypothermia on NO-Mediated Neurogenic Relaxation and on Hypoxic Inhibition in the Response of Canine Cerebral Arteries
- Comparison of Neurogenic Contraction and Relaxation in Canine Corpus Cavernosum and Penile Artery and Vein
- Renin in Cultured Cells of Neural Crest Origin : Abstract : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- CADMIUM-INDUCED INHIBITION OF TWITCHES IN ISOLATED RAT DIAPHRAGM
- AGE-DEPENDENCE OF THE CHRONOTROPIC RESPONSE TO NORADRENALINE, ACETYLCHOLINE AND TRANSMURAL STIMULATION IN ISOLATED RABBIT ATRIA
- PARTICIPATION OF CALCIUM AND SODIUM IONS IN GENESIS OF THE CHRONOTROPIC EFFECT OF NOREPINEPHRINE IN ISOLATED RABBIT SINOATRIAL NODES
- DIFFERENT RESPONSES TO PROSTAGLANDINS E1 AND E2 OF ISOLATED CANINE CORONARY ARTERIES
- EFFECTS OF 5-HYDROXYINDOLEACETIC ACID ON ISOLATED CANINE CEREBRAL ARTERIES
- ANALYSIS OF THE CONTRACTILE RESPONSE TO SEROTONIN AND TRYPTAMINE OF ISOLATED DOG CEREBRAL, FEMORAL AND MESENTERIC ARTERIES
- STRUCTURE-ACTIVITY RELATIONSHIP OF 5-HYDROXYKYNURENAMINE ANALOGUES IN ISOLATED DOG CEREBRAL ARTERIES
- Mechanism Underlying Endothelium-Dependent Relaxation by 2-Methylthio-ADP in Monkey Cerebral Artery
- Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries
- Isobaric Analogue Resonances in ^Al Studied with the ^Mg (p, p) and ^Mg (p, γ) Reactions
- Effects of DX-9065a, an Inhibitor of Factor Xa, on Ellagic Acid-Induced Plantar Skin Thrombosis Assessed in Tetrodotoxin- and N^ω -Nitro-L-Arginine- Treated Rats
- POTENTIATION OF THE CONTRACTILE RESPONSE OF ISOLATED AORTAE TO TRANSMURAL STIMULATION BY ANGIOTENSIN
- Glycosphingolipid receptors for pathogenic vibrios in intestines of mariculture fish
- ANTIARRHYTHMIC ACTIVITY OF DEXTRO- AND LEVO-ISOMERS OF 5-METHYL-8-(2-HYDROXY-3-T-BUTYLAMINO-PROPOXY) COUMARIN HYDROCHLORIDE (BUCUMOLOL), A β-ADRENERGIC BLOCKING AGENT, ON ACONITINE-INDUCED ATRIAL AND OUABAIN-INDUCED VENTRICULAR ARRHYTHMIAS IN DOGS
- PHARMACOLOGY OF dl-5-METHYL-8-(2-HYDROXY-3-t-BUTYLAMINOPROPOXY) COUMARIN HYDROCHLORIDE (CS-359), A NEW β-ADRENERGIC BLOCKING AGENT
- Interactions of ANP, nitroglycerin, sodium nitroprusside, and nitric oxide in isolated dog coronary arteries
- EFFECTS OF BARIUM ON MEMBRANE POTENTIALS OF THE SINO-ATRIAL NODE IN RESPONSE TO SYMPATHETIC NERVE STIMULATION
- CONTRACTILE RESPONSES OF SPIRAL STRIPS OF LARGE BLOOD VESSELS FROM RABBITS TO TRANSMURAL STIMULATION AND TYRAMINE
- EDRF in Human Coronary Arteries : ROLES OF VASCULAR ENDOTHELIUM IN REGULATION OF CARDIOVASCULAR SYSTEM
- MODIFICATION BY AZ-55, GUANETHIDINE AND BRETYLIUM OF RESPONSES OF ATRIA AND AORTIC STRIPS TO TRANSMURAL STIMULATION
- MODIFICATION OF ANGIOTENSIN II-INDUCED RELAXATION BY DIPYRIDAMOLE, PHTHALAZINOL AND ASPIRIN IN ISOLATED DOG RENAL ARTERIES
- CONTRACTILE RESPONSES OF ISOLATED RABBIT AORTAE TO TRANSMURAL STIMULATION AS AFFECTED BY CALCIUM, STRONTIUM, SODIUM AND OUABAIN
- roxidergic Nerves and Hypertension
- Cerebral Vasodilators
- Comparison of the Effect of Dopamine in Primate Arteries and Veins
- EFFECTS OF ANISOTROPINE METHYLBROMIDE (VALPIN®) AND ITS MIXTURE WITH SULPYRINE ON VOCALIZATION RESPONSE AND SPASM OF INTESTINE INDUCED BY ACETYLCHOLINE IN DOGS
- Two Distinct Effects of cGMP on Cytosolic Ca^ Concentration of Rat Pancreatic β-Cells
- SELECTIVE ABOLITION OF Ca-DEPENDENT RESPONSES OF SMOOTH AND CARDIAC MUSCLES BY FLUNARIZINE
- ROLE OF CALCIUM IONS AND ENDOTHELIUM IN THE STRETCH-INDUCED CONTRACTILE ACTIVATION OF VASCULAR TISSUES
- Cilostazol's Effect on the Response to Perivascular Nerve Stimulation in Isolated Dog Cerebral and Mesenteric Arteries
- Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide-Mediated Relaxation in Isolated Monkey Coronary Artery : the Role of Intracellular Superoxide
- Inhibition of Untransformed Prostaglandin H_2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A_2 Inhibitor
- AUTOMATICITY INDUCED BY Ca++ CHELATING AGENTS IN ISOLATED RABBIT LEFT ATRIA
- Chronic Administration of Nicotine-Free Cigarette Smoke Extract Impaired Endothelium-Dependent Vascular Relaxation in Rats via Increased Vascular Oxidative Stress
- Nitrergic nerves derived from the pterygopalatine ganglion innervate arteries irrigating the cerebrum but not the cerebellum and brain stem in monkeys
- Role of Secretory Phospholipase A2 in Rhythmic Contraction of Pulmonary Arteries of Rats With Monocrotaline-Induced Pulmonary Arterial Hypertension
- LENGTH-TENSION RELATIONSHIP IN ISOLATED CANINE CEREBRAL ARTERIES
- Role of Secretory Phospholipase A_2 in Rhythmic Contraction of Pulmonary Arteries of Rats With Monocrotaline-Induced Pulmonary Arterial Hypertension
- SEROTONIN ANTAGONISM IN ISOLATED CANINE CEREBRAL ARTERIES
- ANTIARRHYTHMIC POTENCY OF N-PROPYL AJMALINE WITH UNTOWARD RESPONSE OF VENTRICULAR FIBRILLATION IN EXCESS DOSE
- EFFECTS OF CATECHOLAMINES INJECTED INTO SINOATRIAL NODAL CELLS ON THEIR ELECTRICAL ACTIVITY
- Differences in Adrenergic Nerve and Receptor Function in Dog Internal Thoracic, Coronary and Mesenteric Arteries.
- Comparison of Endothelium-Dependent Responses of Canine Internal Thoracic and Coronary Arteries.
- Effects of Atorvastatin, Amlodipine, and Their Combination on Vascular Dysfunction in Insulin-Resistant Rats
- The regional difference of relaxations induced by various vasodilators in isolated dog coronary and mesenteric arteries.
- EFFECTS OF DOPAMINE AND DOPA ON THE ISOLATED RABBIT'S ATRIUM TREATED WITH RESERPINE
- Role of nitric oxide in non-adrenergic, non-cholinergic nerve-mediated relaxation in dog duodenal longitudinal muscle strips.
- Endothelium-dependent changes in the response to vasoconstrictor substances of isolated dog mesenteric veins.
- Alpha adrenoceptor subtypes responsible for dopamine-induced mesenteric vein contraction.
- Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts