Antagonistic Effect of N-Methyltyramine on α_2-Adrenoceptor in Mice
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概要
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We examined the effect of N-methyltyramine (NMT) on α2-adrenoceptor. NMT (10-8 - 10-3 M) inhibited the binding of [3H]p-aminoclonidine to α2-adrenoceptor dose-dependently. However, the IC50 value for NMT (5.53×10-6 M) was higher than that for RX821002, an α2-adrenoceptor antagonist (1.07×10-8 M). RX821002 (5 mg/kg, i.p.) inhibited hypermotility induced by scopolamine (8 mg/kg, s.c.) in male ddY mice. NMT (20 or 100 mg/kg, i.p.) was found to have a dose-dependent inhibitory effect similar to that of RX821002. These findings indicate that NMT has the properties of an α2-adrenoceptor antagonist. However, the affinity of NMT for α2-adrenoceptor is weaker than that of RX821002.
- 社団法人 日本薬理学会の論文
著者
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辻 浩一
Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.
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Ishida H
School Of Pharmaceutical Science University Of Shizuoka
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Ishida Hitoshi
Department of cardiology, Saitama Medical University, International Medical center
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Tsuji Kiyoshi
Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Hirai Kuniaki
Products Safety & Akohol Science Laboratory Suntory Limited
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KODA Hirofumi
Products Safety & Akohol Science Laboratory, Suntory Limited
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YOKOO Yoshiaki
Technical Development Department, Suntory Limited
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MATSUMOTO Nobuya
Technical Development Department, Suntory Limited
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SUWA Yoshihide
Products Safety & Akohol Science Laboratory, Suntory Limited
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FUKAZAWA Hirotatsu
Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University o
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TSUJI Kuniro
Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University o
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NUKAYA Haruo
Department of Medicinal Chemistry of Natural Product, School of Pharmaceutical Science, University o
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KURIYAMA Kinya
Kyoto Prefectural University of Medicine
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Hirai K
Sankyo Co. Ltd. Kanagawa Jpn
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Tsuji K
School Of Pharmaceutical Science University Of Shizuoka
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辻 京子
Faculty Of Pharmaceutical Sciences Setsunan University
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Nukaya H
School Of Pharmaceutical Science University Of Shizuoka
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Yokoo Yoshiaki
Technical Development Department Suntory Limited
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Suwa Yoshihide
Products Safety & Akohol Science Laboratory Suntory Limited
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Ishida Hitoshi
Research Institute For Bioresources Okayama University:(present Office)plant Protection Station Moji
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Fukazawa H
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Matsumoto Nobuya
Technical Center Suntory Ltd.
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Matsumoto Nobuya
Technical Development Department Suntory Limited
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Ishida Hitoshi
Department Of Cardiology Saitama Medical University International Medical Center
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Ishida Hitoshi
Department Of Applied Chemistry Faculty Of Engineering Kumamoto University
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Fukazawa Hirotatsu
Department of Bioactive Molecules, National Institute of Infectious Diseases
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