EFFECTS OF HARMALINE ON MEMBRANE EXCITABILITY AND ATPase ACTIVITY OF THE CRAYFISH GIANT AXON
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概要
- 論文の詳細を見る
Effects of harmaline on excitability of crayfish giant axon in relation to effects on Na, K-ATPase activity were investigated and the findings were compared with relative data on ouabain. Exposure of the axon to harmaline in doses over 0.5 mM resulted in a dose-dependent reduction of the action potential. Harmaline of 2.5 mM produced a complete blockade of the action potential with a slight decrease in the resting membrane potential (5.7 mV), but no alterations of Na, K-ATPase activity. In contrast, ouabain (5 mM) produced a more pronounced decrease in the resting membrane potential (10.6 mV) and also a partial reduction in the action potential, while a significant decrease in Na, K-ATPase activity was obtained. Increasing the membrane potential to the initial level resulted in a partial recovery (46%) of the rising rate (dV/dt) of action potential. The dV/dt was exponentially decreased when the resting potential was reduced with application of KCl solution over 8 mV. These results suggest that harmaline externally applied produces a decrease in sodium conductance without affecting Na, K-ATPase activity, while ouabain inhibits Na, K-ATPase activity and, to lesser extent, decreases in sodium conductance.
- 社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Ishida Hajime
Department Of Anatomy Faculty Of Medicine University Of The Ryukyus
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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Ishida Hitoshi
Department Of Cardiology Saitama Medical University International Medical Center
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Ishida Hitoshi
Department Of Applied Chemistry Faculty Of Engineering Kumamoto University
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ISHIDA Hajime
Department of Pharmacology, School of Dentistry, University of Tokushima
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