Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation.
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概要
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The effects of anti-vertigo drugs on medial vestibular nucleus (MVN) neurons were examined to assess the site and mode of action using cats anesthetized with α-chloralose. Single neuron activity in the MVN was extracellularly recorded using a silver wire microelectrode attached along a seven-barreled micropipette, each of which was filled with diphenhydramine, diphenidol, betahistine, glutamate or NaCl. Type I of the MVN neurons were identified according to the responses obtained when the animal placed on a turn-table was rotated sinusoidally. The effects of the drugs were examined on type I neurons which received impulses primarily from the labyrinth and sent them to the oculomotor nuclei. The microiontophoretic application of diphenhydramine, diphenidol and betahistine inhibited rotation-induced firing of type I MVN neurons. Diphenhydramine and diphenidol were more potent than betahistine. These results suggest that these drugs directly act on MVN neurons to reduce the responsiveness to rotatory stimulation.
- 公益社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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SASA MASASHI
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Kawabata Atsuhiko
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Kishimoto Takuzo
Department of Pharmacology, Faculty of Medicine, Kyoto University
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