Effect of Hydrogen Peroxide on Guinea Pig Nasal Mucosa Vasculature
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概要
- 論文の詳細を見る
The effect of hydrogen peroxide (H2O2) on guinea pig nasal mucosa vasculature was studied by in vitro assay. H2O2 elicited relaxation of guinea pig nasal mucosa strips precontracted with phenylephrine in a concentration-dependent manner. The relaxant response to H2O2 was abolished in the presence of catalase. Preincubation of the strips with NG-nitro-L-arginine methyl ester or methylene blue significantly attenuated the relaxant responses elicited by H2O2. Fluorescence caused by DAF-2 DA, a fluorescence indicator for nitric oxide, was observed along the nasal mucosa vasculature in response to H2O2. These results suggest that H2O2 induced relaxation of the guinea pig nasal mucosa vasculature and that this relaxation in mediated by the NO/cGMP pathway.
- 社団法人 日本薬理学会の論文
- 2000-12-01
著者
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Sasa Masashi
広島大学 耳鼻咽喉科
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TSURU Hiromichi
Department of Pharmacology, Toho University School of Medicine
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TAKUMIDA Masaya
Department of Otolaryngology, Hiroshima University School of Medicine
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Tsuru Hiromichi
Department Of Pharmacology Faculty Of Medicine Toho University
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HIRAI Tomohisa
Department of Otorhinolaryngology, Hiroshima University School of Medicine
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TANIMITSU Noriaki
Department of Otorhinolaryngology, Hiroshima University School of Medicine
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YAJIN Koji
Department of Otorhinolaryngology, Hiroshima University School of Medicine
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Sasa M
Hiroshima Univ. School Of Medicine Hiroshima Jpn
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Yajin Koji
Department Of Otorhinolaryngology Hiroshima University School Of Medicine
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Yajin Koji
Department Of Otorhinolaryngology Hiroshima University Faculty Of Medicine
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Hirai Takao
Department Of Otorhinolaryngology Hiroshima University School Of Medicine
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Tsuru H
Department Of Pharmacology Toho University School Of Medicine
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Takumida Masaya
Department Of Otolaryngology Hiroshima University School Of Medicine
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Takumida Masaya
Department Of Otorhinolaryngology Hiroshima University School Of Medicine
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Watanabe H
Department Of Otorhinolaryngology Hiroshima University School Of Medicine
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Tanimitsu Noriaki
Department Of Otorhinolaryngology Hiroshima University School Of Medicine
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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YAJIN Koji
Department of Otolaryngology, Head and Neck Surgery, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University
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