Molecular Characterization of the Transmission between the Colonization of Methicillin-resistant Staphylococcus aureus to Human and Environmental Contamination in Geriatric Long-term Care Wards

スポンサーリンク

概要

• 論文の詳細を見る

• Objective Transmission between human and environmental contamination from colonized methicillin-resistant Staphylococcus aureus (MRSA) remains a controversial issue. We, therefore, investigated the differences between MRSA types which colonize in humans and in the environment. Methods A 4-week prospective culture survey for MRSA was performed for 12 patients as well as for the environment of the room of MRSA carriers in quarantine in the geriatric long-term care ward of a 270-bed hospital. Results A total of 97 S. aureus strains (80 MRSA and 17 methicillin-sensitive Staphylococcus aureus [MSSA]) was isolated during the periods of September 8 to 10, 23 to 25 and October 5 to 7, 1998; 25 strains were from the respiratory tract, 4 strains from feces and 11 strains from decubitus ulcers. Fifty-seven strains were from the patients' environment. Molecular typing by pulsed-field gel electrophoresis (PFGE) with the Sma I restriction enzyme demonstrated that the predominant type of MRSA isolated from the environment changed by the minute. The patterns of 42 MRSA strains isolated from the environment were identical in 26 (61.9%), closely related in 15 (35.7%) and possibly related in 1 (2.4%) of the cases of those isolated from patients simultaneously. There was no correlation between patients and the environment with the 17 MSSA isolates. Conclusion Our results demonstrated that MRSA from patients can contaminate the environment, whereas MRSA from the environment might be potentially transmitted to patients via health care workers under unsatisfactory infection control.

• 日本内科学会,The Japanese Society of Internal Medicineの論文
• 2005-01-01

著者

• 渡辺 浩

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• NAGATAKE Tsuyoshi

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• Watanabe Kiwao

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• Watanabe Hiroshi

  Department of Cardiology, Niigata City General Hospital

• OISHI Kazunori

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• MASAKI HIRONORI

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• 渡辺 貴和雄

  Department Of Internal Medicine International Research Center For Infectious Diseases Institute Of M

• Watanabe K

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Watanabe Kiwao

  Department Of Clinical Medicine Institute Of Tropical Medicine Nagasaki University

• Asoh Norichika

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Oishi Kazunori

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Matsumoto Keizo

  Professor Emeritus Nagasaki Univ.

• Nagatake T

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Nagatake Tsuyoshi

  Laboratory For Electron Microscopy And Department Of Internal Medicine Institute Of Tropical Medicin

• Nagatake Tsuyoshi

  Department Of Electrical And Electronics Engineering Chiba University

• Matsumoto K

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• MITSUSIMA Hiroaki

  Department of Internal Medicine, Aino Memorial Hospital

• MATSUMOTO Keizou

  Department of Internal Medicine, Aino Memorial Hospital

• Masaki H

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Masaki Hironori

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Matsushima Kouji

  Department Of Allergy And Immunology National Research Institute For Child Health & Development

• Matsuno Kenjiro

  Department Of Anatomy (macro) & Sorst Dokkyo University School Of Medicine

• Matsushima Kouji

  Department Of Molecular Preventive Medicine & Sorst Graduate School Of Medicine University Of To

• Matsushima K

  Department Of Allergy And Immunology National Research Institute For Child Health & Development

• Mitsusima Hiroaki

  Department Of Internal Medicine Aino Memorial Hospital

• Watanabe Hiroshi

  Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers

関連論文

• Novel Preparation of Intercellular Lipid Models of the Stratum Corneum Containing Stereoactive Ceramide
• 下気道感染症に対する ceftazidime を対照とする cefozopran の市販後臨床試験
• 慢性気道感染症に対するgrepafloxacinとofloxacinの二重盲検比較試験
• 慢性気道感染症に対するgrepafloxacinの用量比較試験
• 慢性気道感染症に対するTazobactam/PiperacillinとPiperacillinの薬効比較試験成績
• 細菌性肺炎に対するciprofloxacin注射薬の臨床評価-Ceftazidime-を対照薬とした第III相臨床比較験
• 内科的治療に苦慮し肺切除に到った Mycobacterium chelonae の1例
• ベトナムにおける小児上気道由来と髄液由来インフルエンザ菌に対する分子疫学的検討
• SARSの現状と冬季流行への警鐘と対策 (特集 プライマリケア医のためのかぜ症候群とインフルエンザの診かた)
• 外来発症で遷延化した偽膜性大腸炎の1例
• MRSA便培養陽性18例の臨床的検討 : 特に腸炎発症例と定着症例の比較について
• 老人病棟において分離された気道由来 Staphylococcus aureus の薬剤感染性に関する検討
• 院内感染対策継続中の老人病棟MRSA専用室における患者および環境からのグラム陰性菌の検出状況
• 院内肺炎の発症予防におけるポビドンヨードによる上気道清浄化の有用性
• 呼吸器感染症におけるcefluprenamの基礎的・臨床的研究
• Nosocomial Bacteremia Caused by Biofilm-Forming Bacillus cereus and Bacillus thuringiensis
• 緑膿菌由来のIL-8誘導蛋白の生物学的活性とその臨床的意義
• Anti-Endothelial Cell Antibodies in the Sera of Patients with Mixed Connective Tissue Disease - The Clinical Significance
• Endovascular Stent-Grafting for Recurrent Aneurysm in Behcets Disease
• Heterotopic sebaceous glands in the esophagus : Histopathological and immunohistochemical study of a resected esophagus
• Solitary esophageal metastasis of breast cancer with 15 years' latency : A case report and review of the literature
• Significant Reduction of Methicillin-resistant Staphylococcus aureus Bacteremia in Geriatric Wards after Introduction of Infection Control Measures against Nosocomial Infections
• Causative bacteria of respiratory tract infections in Kuwait by quantitative culture of sputum
• Attachment of Nontypable Haemophilus influenzae to Human Pharyngeal Epithelial Cells Mediated by a Ganglioside Receptor
• Changes in Antimicrobial Susceptibility to Moraxella catarrhalis over a Ten-Year Period
• Moraxella(Branhamella) catarrhalis Adherence to Human Bronchial and Oropharyngeal Cells:The Role of Adherence in Lower Respiratory Tract Infections
• 老人病棟における院内感染対策継続による菌血症及び院内肺炎の減少と起炎菌の変貌
• PE-150 Comparison of Dilated Cardiomyopathy and Coronary Artery Disease in Effectiveness of Dl-sotalol on the Recurrence of Ventricular Tachyarrhythmia(Arrhythmia, therapy-10 (A) PE25,Poster Session (English),The 70th Anniversary Annual Scientific Meeting
• Efficacy of Bepridil for Antiarrhythmic Drug Refractory Ventricular Tachyarrhythmias in ICD Patients with Structural Heart Disease(Arrhythmia, Pharmacological Therapy 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Possible Prevalence and Transmission of Acute Respiratory Tract Infections Caused by Streptococcus pneumoniae and Haemophilus influenzae among the Internally Displaced Persons in Tsunami Disaster Evacuation Camps of Sri Lanka
• RNA Editing and Short Variant of Serotonin 2C Receptor mRNA in Neuronally Differentiated NG108-15 Cells
• Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
• RNA Editing and Short Variant of Serotonin 2C Receptor mRNA in Neuronally Differentiated NG108-15 Cells
• Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells
• PJ-093 Extracellular but not Intracellular Acidosis Suppresses Endothelial Function by Inhibiting Intracellular Calcium Responses(Endothelium(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• IS121 Regulation of capacitative Ca^2+ influx in human monocytes/macrophages by myosin light-chain kinase
• Regulation of Bradykinin-Stimulated Cation Entry Into Endothelial Cells by tyrosine Kinase
• Excessive nitric oxide production and cardiac dysfunction in patients with chronic renal failure
• 慢性気道感染症に対するgatifloxacinの臨床的検討-その喀痰中移行と細菌学的効果-
• A Phase III, Multicenter, Collaborative, Open-Label Clinical Trial of Sildenafil in Japanese Patients With Pulmonary Arterial Hypertension
• P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caco-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines
• PJ-566 Influence of CYP2C9 Genotype on Pharmacokinetics and Pharmacodynamics of Benzbromarone(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-561 Antiproliferative Effect of Cyclic AMP on Human Umbilical Vein Endothelial Cells through TGF-beta Inducing p21(Cip1/Waf1) Expression(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
• OJ-002 Influence of Genetic Polymorphisms of OATP-C on Cholesterol Lowering Effect of Pravastatin(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
• 4 Inhibition of Type-5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension(Which drug is useful for the treatment of pulmonary hypertension?,Topic 4 (TP4) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Long-Term Survival in Patients with Pulmonary Hypertension Treated with a Type 5 Phosphodiesterase Inhibitor Sildenafil(Pulmonary Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OE-271 Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolaemia and hypertension(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
• Assessment of Forearm Reactive Hyperemia Using Near-Infrared Time-Resolved Spectroscopy : A New Tool to Evaluate Endothelial Function
• 呼吸器感染症におけるgrepafloxacinの基礎的・臨床的研究
• 過去10年間における放射線肺臓炎の臨床的検討
• 最近の4年間における,市中肺炎の起炎菌とその臨床的解析
• Acceptor Concentration Control of P-ZnSe Using Nitrogen and Helium Mixed Gas Plasma
• Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
• 髄膜炎
• Rapid Increase of Pneumococcal Resistance to β-Lactam and Other Antibiotics in Isolates from the Respiratory Tract(Nagasaki, Japan:1975-1994)
• Bactericidal Activity in Filtrated Supernatant of Streptococcus Sanguinis against Multidrug-Resistant Pseudomonas Aeruginosa
• ベトナムの小児急性下気道感染症における薬剤耐性肺炎球菌
• Prevalence of Haemophilus influenzae with resistant genes isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam
• Clinical and microbiological characteristics of community-acquired pneumonia among human immunodeficiency virus-infected patients in northern Thailand.
• Increased Rates of Intense Nasopharyngeal Bacterial Colonization of Vietnamese Children with Radiological Pneumonia
• Strain-Specific Pulmonary Defense Achieved after Repeated Airway Immunizations with Non-Typeable Haemophilus Influenzae in a Mouse Model
• Molecular Characterization of the Transmission between the Colonization of Methicillin-resistant Staphylococcus aureus to Human and Environmental Contamination in Geriatric Long-term Care Wards
• 呼吸器感染症におけるPK/PD解析
• 急性気管支炎に抗菌薬は必要か (第5土曜特集 抗菌薬 UPDATE) -- (第3章 抗菌薬をめぐるコントラバーシ)
• Possible Relationship between Staphylococcus aureus Colonizing the Respiratory Tract and Rectum and S. aureus Isolated in a Geriatric Hospital Environment
• Enterocolitis Caused by Methicillin-Resistant Staphylococcus aureus: Molecular Characterization of Respiratory and Digestive Tract Isolates
• 発熱から何を考えるか(忘れてはならない感染症)
• The Effects of S-Carboxymethylcysteine and N-Acetylcysteine on the Adherence of Moraxella catarrhalis to Human Pharyngeal Epithelial Cells
• 喀痰中MRSA保菌者についての臨床的検討
• Role of Lipooligosaccharide in the Attachment of Moraxella catarrhalis to Human Pharyngeal Epithelial Cells
• A clinical, serological, and immunological study in a Japanese traveler with dengue fever
• Induction of Interleukin 8 (IL-8) Production by Pseudomonas Nitrite Reductase in Human Alveolar Macrophages and Epithelial Cells
• Possible Relationship of PFGE Patterns of Moraxella catarrhalis between Hospital- and Community-Acquired Respiratory Infections in a Community Hospital
• Antimicrobial Effect of Fluoroquinolones for the Eradication of Nontypeable Haemophilus Influenzae Isolates within Biofilms
• Airway Interleukin-8 in Elderly Patients with Bacterial Lower Respiratory Tract Infections
• Association of dengue virus type-specific IgG on platelets is specific for the acute phase in an imported Japanese patient with secondary dengue 2 virus infection
• エイズの防疫と治療戦略 8 タイ国北部地域におけるHIV陽性患者に合併した呼吸器感染症の臨床的検討
• Pulmonary infection caused by Rhodococcus equi in HIV-infected patients: report of four patients from northern Thailand
• Possible Relationship between Staphylococcus aureus Colonizing the Respiratory Tract and Rectum and S. aureus Isolated in a Geriatric Hospital Environment
• Clinical Evaluation of Polymerase Chain Reaction DNA Amplification Method for the Diagnosis of Pulmonary Tuberculosis in Patients with Negative Acid-fast Bacilli Smear
• 抗インフルエンザ薬の現状と将来 (特集 インフルエンザウイルス感染症の最新の話題)
• 市中肺炎における levofloxacin 注射剤の ceftriaxone sodium を対照とした第III相比較試験
• 感染制御関連学会/研究会・最新の話題 第45回緑膿菌感染症研究会
• 注目の新薬 イナビル吸入粉末剤
• Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2008 : general view of the pathogens' antibacterial susceptibility
• 新規抗インフルエンザ薬 (特集 抗ウイルス薬) -- (新規抗ウイルス薬の開発動向と展望)
• NHCAP治療区分の考え方 (特集 医療・介護関連肺炎(NHCAP)診療ガイドラインのすべて)
• 注射用シプロフロキサシンの高用量投与の必要性に関するアンケート調査結果報告
• 低蔓延国を目指して
• 抗菌薬使用法のこれまでとこれから (特集 系統別 抗菌薬の使い方・止め方・変え方)
• 肺炎診療の実際-外来治療から入院・ICU治療まで
• 座談会 抗インフルエンザ薬による予防 : 高齢者を中心に
• 抗インフルエンザウイルス薬 : 新規薬剤を中心に (特集 新しい治療薬と呼吸器感染症診療の展開)
• Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRS A : a prospective observational study
• 薬剤耐性菌用薬 (特集 抗菌薬と抗ウイルス薬 : 正しい使い方) -- (各種抗菌薬の使い方)
• 抗菌薬療法の考え方 : PK-PD理論
• 抗菌薬開発の現況と今後の展望 (特集 感染症医薬品開発の現況) -- (感染症医薬品開発の現況と今後の展望)
• インフルエンザ診療の新たな展開 : 抗インフルエンザ薬を中心に (大阪府内科医会 第21回医学会(四府県内科医会合同学術講演会))
• 最近の肺炎球菌性肺炎 (特集 肺炎診療の新しい潮流)
• Nationwide, multicenter survey on the efficacy and safety of piperacillin for adult community-acquired pneumonia in Japan

もっと見る 閉じる

スポンサーリンク