Clinical and microbiological characteristics of community-acquired pneumonia among human immunodeficiency virus-infected patients in northern Thailand.
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概要
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The original publication is available at www.springerlink.comHuman immunodeficiency virus (HIV) infections are prevalent in Thailand. However, the clinical and microbiological characteristics of community-acquired pneumonia (CAP) in such patients are not completely clear at present. In the present study, we analyzed the characteristics of CAP in 191 HIV-infected patients (192 episodes, 130 males and 61 females, mean age 32.9 years, range: 20-62) who had been admitted to Nakornping Hospital in northern Thailand between December 1996 and January 2002. The mean peripheral blood CD4 lymphocyte count was 68.5/mm3 (range: 0-791). The most common organisms detected in the blood of the subjects were as follows: Penicillium marneffei, 13, Salmonella spp., 5, Cryptococcus neoformans, 4, Staphylococcus aureus, 3, and Rhodococcus equi, 3, and the most common organisms detected in sputum included Haemophilus influenzae, 38, P. marneffei, 10, Streptococcus pneumoniae, 10, R. equi, 9, and S. aureus, 9. Life-threatening meningitis in 5 (cryptococcal in 3 and tuberculous in 2), pneumothorax in 2, and tuberculous lymphadenitis in 1 were also noted, resulting in 21 fatalities (10.9%). The mean peripheral blood CD4 lymphocyte count for cases in which the subject died was 74.8/mm3 (range: 0-340). Logistic regression analysis demonstrated that high age (odds ratio of over 40 years: 15.62) and R. equi infection (odds ratio: 8.14) are related to death of HIV-infected patients with CAP. The above findings indicate that various types of organisms, including mixed organisms, cause CAP in HIV-infected patients in northern Thailand, and high age and R. equi infection seem to be risk factors for death.
- Springer Japanの論文
- 2008-04-01
著者
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渡辺 浩
Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University
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NAGATAKE Tsuyoshi
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
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Watanabe Kiwao
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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OISHI Kazunori
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
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渡辺 貴和雄
Department Of Internal Medicine International Research Center For Infectious Diseases Institute Of M
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Watanabe K
Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University
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Watanabe Kiwao
Department Of Clinical Medicine Institute Of Tropical Medicine Nagasaki University
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Asoh Norichika
Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University
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Oishi Kazunori
Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University
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Nagatake T
Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University
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Nagatake Tsuyoshi
Laboratory For Electron Microscopy And Department Of Internal Medicine Institute Of Tropical Medicin
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Nagatake Tsuyoshi
Department Of Electrical And Electronics Engineering Chiba University
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KOBAYASHI Shinobu
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University
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KOSITSAKULCHAI Weerayut
Nakornping Hospital
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SANCHAI Tippaya
Nakornping Hospital
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KHANTAWA Banyong
Department of Microbiology, Faculty of Medicine, Chiang Mai University
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THARAVICHITKUL Prasit
Department of Microbiology, Faculty of Medicine, Chiang Mai University
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SIRISANTHANA Thira
Research Institute for Health Sciences, Chiang Mai University
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Kobayashi Shinobu
Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University
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Sirisanthana T
Research Institute For Health Sciences Chiang Mai University
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Tharavichitkul P
Department Of Microbiology Faculty Of Medicine Chiang Mai University
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Khantawa Banyong
Department Of Microbiology Faculty Of Medicine Chiang Mai University
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Sirisanthana Thira
Research Institute For Health Sciences
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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