Nosocomial Bacteremia Caused by Biofilm-Forming Bacillus cereus and Bacillus thuringiensis

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概要

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• Objective Bacterial biofilms cause serious problems, such as antibiotic resistance and medical device-related infections. Recent reports indicate that Bacillus species potentially form biofilms and cause nosocomial bacteremia via catheter infection. Our objective was to investigate the relationship between nosocomial bacteremia caused by Bacillus species and biofilm formations. Methods Between 2001 and 2006, Bacillus cereus and Bacillus thuringiensis were isolated from blood samples of 21 patients with nosocomial bacteremia in two hospitals. The patients had underlying diseases such as cerebrovascular damage, malignant disease, or chronic obstructive lung disease and had high fever at the onset of bacteremia. After investigation, B. cereus and B. thuringiensis were isolated from patients catheter tip, gauze, and hospital environment. Pulsed-field gel electrophoresis (PFGE) on 32 B. cereus and 7 B. thuringiensis isolates, microtiter biofilm assay and scanning electron microscopy (SEM) on 22 B. cereus isolates from patients blood were performed. Results Molecular analysis by PFGE showed that 32 B. cereus strains had 21 patterns and 7 B. thuringiensis strains had 3 patterns. The PFGE patterns of B. thuringiensis and B. cereus in blood samples from 2 patients blood were similar to those from the same patients catheter tip. The PFGE pattern of B. cereus from a hospital environment was similar to that from 2 patients blood samples, and the PFGE pattern of B. thuringiensis from 2 hospital environments was similar to that from 2 patients blood. The biofilm formations by 22 B. cereus isolates from patients blood were confirmed by microtiter biofilm assay and SEM even at 24 hours. Conclusion Our data indicate that various types of Bacillus species exist in hospital environments and the biofilm-forming strains potentially cause nosocomial bacteremia by catheter infection.

著者

• Kuroki Reiki

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• Kawakami Kenji

  Nagasaki Medical Center of Neurology

• Qin Liang

  Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medi

• Kaji Chiharu

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• Watanabe Kiwao

  Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

• Kimura Yumiko

  Nagasaki Medical Center of Neurology

• Ishiguro Chiaki

  Yamada Red Cross Hospital

• Tanimura Shinobu

  Yamada Red Cross Hospital

• Tsuchiya Yukiko

  Yamada Red Cross Hospital

• Hamaguchi Ichiro

  Yamada Red Cross Hospital

• Sakakura Mitsuru

  Yamada Red Cross Hospital

• Sakabe Shigetoshi

  Yamada Red Cross Hospital

• Tsuji Kota

  Yamada Red Cross Hospital

• Inoue Masakazu

  Yamada Red Cross Hospital

• Watanabe Hiroshi

  Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medi

• Qin Liang

  Division Of Infectious Diseases Department Of Infectious Medicine Kurume University School Of Medici

• Watanabe Kiwao

  Department Of Clinical Medicine Institute Of Tropical Medicine Nagasaki University

• Kaji Chiharu

  Department Of Bacteriology Ii National Institute Of Infectious Diseases

• Watanabe Hiroshi

  Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science

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