Antihypertensive and Neuroprotective Effects of Astaxanthin in Experimental Animals(Pharmacology)
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概要
- 論文の詳細を見る
Astaxanthin is a natural antioxidant carotenoid that occurs in a wide variety of living organisms. We investigated, for the first time, antihypertensive effects of astaxanthin (ASX-O) in spontaneously hypertensive rats (SHR). Oral administration of ASX-O for 14 d induced a significant reduction in the arterial blood pressure (BP) in SHR but not in normotensive Wistar Kyoto (WKY) strain. The long-term administration of ASX-O (50 mg/kg) for 5 weeks in stroke prone SHR (SHR-SP) induced a significant reduction in the BP. It also delayed the incidence of stroke in the SHR-SP. To investigate the action mechanism of ASX-O, the effects on PGF_<2α>-induced contractions of rat aorta treated with N^G-nitro-l-arginine methyl ester (L-NAME) were studied in vitro. ASX-O (1 to 10 μM) induced vasorelaxation mediated by nitric oxide (NO). The results suggest that the antihypertensive effect of ASX-O may be due to a NO-related mechanism. ASX-O also showed significant neuroprotective effects in ischemic mice, presumably due to its antioxidant potential. Pretreatment of the mice with ASX-O significantly shortened the latency of escaping onto the platform in the Morris water maze learning performance test. In conclusion, these results indicate that astaxanthin can exert beneficial effects in protection against hypertension and stroke and in improving memory in vascular dementia.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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Watanabe Hiroshi
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medi
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三川 潮
富山医薬大薬
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三川 潮
Faculty Of Pharmaceutical Sciences University Of Tokyo
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GOTO Hirozo
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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Goto Hirozo
Toyama Medical and Pharmaceutical University
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Goto H
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Goto Hirozo
富山大学和漢医薬学総合研究所 病態生化学
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Goto Hirozo
富山大学 大学院医学薬学研究部和漢診療学講座
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Goto H
富山医科薬科大学和漢薬研究所漢方診断学部門
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Goto Hirozo
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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GOTO Hideyuki
GeneCare Research Institute
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Sankawa U
International Research Center For Traditional Medicine
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Sankawa Ushio
(present Address)faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Sankawa Ushio
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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ZHAO Qi
Division of Medicinal Pharmacology, Institute of Natural Medicine,University of Toyama
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HUSSEIN Ghazi
International Research Center for Traditional Medicine
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SANKAWA Ushio
International Research Center for Traditional Medicine
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IGUCHI Tomomi
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical & Pharmaceutical U
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Zhao Qi
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Zhao Qi
Division Of Pharmacology Institute Of Natural Medicine Toyama Medical & Pharmaceutical Universit
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Watanabe Hiroshi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science
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後藤 博三
富山医科薬科大学和漢薬研究所漢方診断学部門
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Iguchi Tomomi
Division Of Pharmacology Institute Of Natural Medicine Toyama Medical & Pharmaceutical Universit
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Hussein Ghazi
International Research Center For Traditional Medicine:division Of Medicinal Pharmacology Institute
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NAKAMURA Masami
Division of Pharmacology, Institute of Natural Medicine, Toyama Medical & Pharmaceutical University
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama : 21st Century Coe
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Watanabe H
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Nakamura Masami
Division Of Pharmacology Institute Of Natural Medicine Toyama Medical & Pharmaceutical Universit
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Watanabe Hiroshi
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science
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