Selective Inhibition of Src Protein Tyrosine Kinase by Analogues of 5-S-Glutathionyl-β-alanyl-L-dopa

概要

論文の詳細を見る
Twelve analogues of the antibacterial phenolic peptide 5-S-glutathionyl-β-alanyl-L-dopa (5-S-GA-L-D : 1) were synthesized via orthoquinones using tyrosinase. Several synthesized compounds inhibited the v-Src autophosphorylation tyrosine kinase reaction with an IC_<50> value comparable to that of herbimycin. The inhibition of c-Src substrate phosphorylation was much less active than v-Src autophosphorylation inhibition. The analogues showed no effects on substrate phosphorylation by epidermal growth factor receptor (EGFR), and this selectivity is the most characteristic feature of the analogues (1-12).
公益社団法人日本薬学会の論文
1998-12-15