10 Ephedrineの生合成
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概要
- 論文の詳細を見る
Using Ephedra distachya L. fed with ^<15>N-phenylalanine, ^<15>N-alanine, ^<14>C-formate, methionine(^<14>CH_3) and ω-aminoacetophenone (Carbonyl^<14>C), Shibata, Imaseki and Yamazaki proposed previously the pathway(Fig 5) for the biosynthesis of 1-ephedrine. On our renewed experiments, it has been found that phenylalanine-2^<14>C was not incorporated into ephedrine, whereas ^3H labelled benzene ring and ^<14>C at the 3-position of phenylalanine were incorporated into the corresponding positions of ephedrine. It has also been shown that ^<14>C-labelled benzoic acid and benzaldehyde were transferred into ephedrine with a very high incorporation ratio. The stereochemistry at the β-position of 1-ephedrine side chain which is reversed to that of L-phenylalanine would be explained by the new biosynthetic scheme which involves the condensation of φ-C_1 and C_2-N units (Fig 7).
- 天然有機化合物討論会の論文
- 1969-09-01
著者
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山崎 和男
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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山崎 和男
広島大薬
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柴田 承二
東大薬
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柴田 承二
東大・薬
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三川 潮
東大薬
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三川 潮
Faculty Of Pharmaceutical Sciences University Of Tokyo
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柴田 承二
柴田天然薬物研究室
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山崎 和男
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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柴田 承二
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)meiji College Of Pharmacy
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柴田 承二
明治薬科大学
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三川 潮
東大 薬
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山崎 和男
東大薬
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