Screening of Plant Constituents for Effect on Glucose Transport Activity in Ehrlich Ascites Tumour Cells

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概要

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• The effect of plant extracts on D-glucose uptake by Ehrlich ascites tumour cells was examined. Among the 23 exracts of medicinal plants, five samples inhibited, and six samples activated, the uptake significantly. From one of the active plants, Lagerstroemia speciosa, two triterpenoids, colosolic acid and maslinic acid were isolated. Colosolic acid was shown to be a glucose transport activator. Scince this compound was known to have hypoglycemic activity, our simple in vitro bioassay method can at least be used as a first screening for anti-diabetic activity.

• 社団法人日本薬学会の論文
• 1993-12-15

著者

• 笠井 良次

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 山崎 和男

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 大谷 和弘

  広島大・医

• 笠井 良次

  広島大・医

• 大谷 和弘

  Institute of Pharmaceutical Sciences, Hiroshima University

• 村上 千景

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 明賀 圭子

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 黒川 知則

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 石橋 貞彦

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• DAYRIT Fabian

  Department of Chemistry, Ateneo de Manila University

• PADOLNA William

  Institute of Chemistry, University of the Philippines at Los Banos

• 石橋 貞彦

  広島大学医学部総合薬学科

• 山崎 和男

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 村上 千景

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 黒川 知則

  広島大医・総合薬・生理化学

• Padolna William

  Institute Of Chemistry University Of The Philippines At Los Banos

• Dayrit Fabian

  Department Of Chemistry Ateneo De Manila University

• 明賀 圭子

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

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