The Biologically Active Constituents of Ganoderma lucidum (FR.) KARST. Histamine Release-Inhibitory Triterpenes
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概要
- 論文の詳細を見る
The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. From the physiologically active fraction of the extract, along with the known triterpenes ganoderic acids A and B, two new triterpenes were isolated and named ganoderic acids C and D. The structures of ganoderic acids C and D were determined to be 3β, 7β, 15α-trihydroxy-11,23-dioxo-5α-lanost-8-en-26-oic acid and 7β-hydroxy-3,11,15,23-tetraoxo-5α-lanost-8-en-26-oic acid respectively. Ganoderic acids C and D were shown to inhibit histamine release from rat mast cells. Quantitative analysis of these triterpenes was performed for the purpose of crude drug quality control.
- 社団法人日本薬学会の論文
- 1985-04-25
著者
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山崎 和男
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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内田 勝
(株)常磐植物化学研究所
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石原 茂正
(株)常磐植物化学研究所
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中村 英雄
Research Laboratories, Tokiwa Phytochemical Co., Ltd.
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内田 勝
Research Laboratories, Tokiwa Phytochemical Co., Ltd.
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菰田 泰夫
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
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山崎 和男
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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平井 裕子
広島大学医学部総合薬学科
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菰田 泰夫
医歯大・医用研・化学
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菰田 泰夫
Institute For Medical And Dental Engineering Tokyo Medical And Detal University
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神田 博史
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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中村 英雄
Research Laboratories Tokiwa Phytochemical Co. Ltd.
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菰田 泰夫
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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