Studies on Vazoactive Heterocyclic Compounds. : Preparation and Evaluation of the Hypotensive and Antiaggregating Activities of Phthalazinol Nitrates

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概要

• 論文の詳細を見る

• Phthalazinol (1) was converted to phthalazinol nitrate (2) and phthalazinol dinitrate (3) by treatment with fuming nitric acid and acetic anhydride. The structures were confirmed by spectral analyses. Introduction of the nitrogen dioxide moiety into the 4-hydroxymethyl group of 1 resulted in a potent hypotensive activity. Furthermore, the antiaggregating activities of 1 were remarkably enhanced by nitration of the 1-oxo and 4-hydroxymethyl groups.

• 公益社団法人日本薬学会の論文
• 1988-07-25

著者

• 菰田 泰夫

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 石川 正幸

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 伊藤 茂

  Institute for Medical and Dental Engineering, Tokyo Medical and Detal University

• 東 洋

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 東 洋

  Department Of Medicinal Chemistry Institute For Medical And Dental Engineering Tokyo Medical Adnd De

• 菰田 泰夫

  医歯大・医用研・化学

• 菰田 泰夫

  Institute For Medical And Dental Engineering Tokyo Medical And Detal University

• 関崎 里美

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 関崎 里美

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 伊藤 茂

  Institute For Medical And Dental Engineering Tokyo Medical And Detal University

• 伊藤 茂

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 菰田 泰夫

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

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