Studies on Hypotensive Agents. Synthesis of 1-Substituted 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H, 3H)-quinazolinediones
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概要
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3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H, 3H)-quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activites on relaxing effects of the blood vessels. The compounds with 2-(1-pyrroidinyl) ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.
- 社団法人日本薬学会の論文
- 1991-07-25
著者
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江口 征夫
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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江口 征夫
日本動脈硬化研究所
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石川 正幸
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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杉本 昭子
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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佐々木 藤紀
Research Laboratory, Banyu Pharmaceutical Co., Ltd.,
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海老沢 久
Life Science Research Laboratory, Showa Denko Co., Ltd.,
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佐々木 藤紀
Banyu Pharmaceutical Co., Ltd.,
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海老沢 久
Life Science Research Laboratory Showa Denko Co. Ltd.
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佐々木 藤紀
Banyu Pharmaceutical Co. Ltd.
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