A New Synthesis of (±)-Trypargine

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概要

• 論文の詳細を見る

• A new route for the synthesis of (±)-trypargine (I) is described. The Pictet-Spengler reaction of N_b-benzyltryptamine with α-ketoglutaric acid was carried out in aprotic media to afford the key intermediate, 2-benzyl-1,2,3,4-tetrahydro-9H-pyrido [3,4-b] indole-1-propionic acid (IIa), which was converted into (±)-trypargine (I) in five or six steps.

• 公益社団法人日本薬学会の論文
• 1982-12-25

著者

• 菰田 泰夫

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 清水 正人

  Research Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 清水 正人

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 中嶋 暉躬

  Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University

• 中嶋 暉躬

  Suntory Institute For Bioorganic Research

• 石川 正幸

  Research Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 石川 正幸

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 菰田 泰夫

  医歯大・医用研・化学

• 菰田 泰夫

  Institute For Medical And Dental Engineering Tokyo Medical And Detal University

• 松原 ゆきみ

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 松原 ゆきみ

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 菰田 泰夫

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

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