Studies on Antiatherosclerotic Agents. Synthesis of 7-Ethoxycarbonyl-4-formyl-6,8-dimethyl-1(2H)-phthalazinone Derivatives and Related Compounds

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概要

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• Derivatives of 7-ethoxycarbonyl-4-formyl-6,8-dimethyl-1(2H)-phthalazinone and closely related compounds were synthesized using Wittig and epoxidation reactions. Ring opening amination of the epoxides were carried out using dimethylaluminum amide reagents under mild reaction conditions. β-Keto ester and β-diketone moieties were introduced through diazo derivatives. These moieties were reacted with hydrazine hydrate to produce 4-pyrazolyl derivatives.The derivatives were tested for their inhibitory effect on platelet aggregation, and their relaxing effect on blood vessels.

• 公益社団法人日本薬学会の論文
• 1991-03-25

著者

• 江口 征夫

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 江口 征夫

  日本動脈硬化研究所

• 中嶋 雅子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 石川 正幸

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 高嶋 芳美

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 佐々木 藤紀

  Banyu Pharmaceutical Co., Ltd.,

• 高嶋 芳美

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 佐々木 藤紀

  Banyu Pharmaceutical Co. Ltd.

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