ASYMMETRIC SYNTHESIS OF (1S)-(-)-TRYPARGINE

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概要

• 論文の詳細を見る

• (1S)-(-)-Trypargine (1a) was synthesized from (1S, 3R)-(-)-2-benzyl-3-(methoxycarbonyl)-1,2,3,4-tetrahydro-9H-pyrido [3,4-b] indole-1-propionic acid (3a), prepared by the asymmetric Pictet-Spengler reaction of N_b-benzyl-(D)-tryptophan methyl ester (2) with α-ketoglutaric acid. The absolute configuration of natural trypargine (1a) at the C_1 position was determined to be the S-configuration.

• 公益社団法人日本薬学会の論文
• 1982-09-25

著者

• 坂井 進一郎

  Faculty of Pharmaceutical Sciences, Chiba University

• 山口 啓一

  Faculty of Pharmaceutical Sciences, Chiba University

• 菰田 泰夫

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 清水 正人

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 中嶋 暉躬

  Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University

• 中嶋 暉躬

  Suntory Institute For Bioorganic Research

• 石川 正幸

  Research Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 石川 正幸

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 菰田 泰夫

  医歯大・医用研・化学

• 菰田 泰夫

  Institute For Medical And Dental Engineering Tokyo Medical And Detal University

• 山口 啓一

  Faculty Of Pharmaceutical Sciences Chiba University

• 坂井 進一郎

  Faculty Of Pharmaceutical Sciences Chiba University

• 菰田 泰夫

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

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