Studies on Peptides. CVI. Synthesis of a Physalaemin-like Peptide, [Lys^5,Thr^6]-Physalaemin, isolated from the Skin of a Frog, Uperoleia rugosa
スポンサーリンク
概要
- 論文の詳細を見る
An undecapeptide amide, H-Pyr-Ala-Asp-Pro-Lys-Thr-Phe-Tyr-Gly-Leu-Met-NH_2,corresponding to the entire amino acid sequence of an amphibian peptide, [Lys^5,Thr^6]-physalaemin, was synthesized using the thioanisole-mediated trifluoromethanesulfonic acid deprotection procedure. The synthetic peptide was as active as the natural peptide, in terms of the contractility in guinea pig ileum, and its potency relative to that of synthetic substance P was 0.467.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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仲田 義啓
広島大学大学院 医歯薬学総合研究科 薬効解析科学
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬川 富郎
Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University
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南竹 義春
Suntory Institute for Biomedical Research
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中嶋 暉躬
Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University
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船越 奨
Faculty of Pharmaceutical Sciences
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仲田 義啓
Institute of Pharmaceutical Sciences, Hiroshima University
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中嶋 暉躬
Suntory Institute For Bioorganic Research
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南竹 義春
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
京都大学
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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片山 逸子
Faculty of Pharmaceutical Sciences, Kyoto University
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安原 正
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
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瀬川 富郎
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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安原 正
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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片山 逸子
Faculty Of Pharmaceutical Sciences Kyoto University
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