Studies on Peptides. CXLVI. : Synthesis of Gln^<15>-Motilin and Examination of Its Immunological Properites
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概要
- 論文の詳細を見る
Gln^<15>-motilin was synthesized in a conventional manner by assembling seven peptide fragments followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid. The usefulness of phenylthiotrimethylsilane for the reduction of Met(O) was confirmed. This motilin analog was as biologically active as synthetic motilin in terms of contraction of rabbit duodenal muscles, but in radioimmunoassay it was only about 25% as reactive with antiserum raised against synthetic porcine motilin.
- 社団法人日本薬学会の論文
- 1986-11-25
著者
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藤井 信孝
京都大学薬学部
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仲田 義啓
広島大学大学院 医歯薬学総合研究科 薬効解析科学
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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井上 敦子
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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別所 清
Faculty Of Pharmaceutical Sciences Kyoto University
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安達 秀樹
University Hospital Faculty Of Medicine Kyoto University
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仲田 義啓
Institute of Pharmaceutical Sciences, Hiroshima University
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瀬川 富朗
Institute of Pharmaceutical Sciences, Hiroshima University
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井上 敦子
Institute of Pharmaceutical Sciences, Hiroshima University
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久野 鈴光
Faculty of Pharmaceutical Sciences, Kyoto University
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久野 鈴光
Faculty Of Pharmaceutical Sciences Kyoto University
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李 惟
Department Of Molecular Biology Jilin University
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李 惟
Faculty of Pharmaceutical Science, Kyoto University
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別所 清
College of Liberal Arts, Kyoto University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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瀬川 富郎
Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University
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藤井 信孝
京都大学
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瀬川 富朗
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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仲田 義啓
広島大学医学部総合薬学科
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