Studies on Peptides. CXXXII. : Evaluation of Two β-Carboxyl Protecting Groups of Aspartic Acid, Cycloheptyl and Cyclooctyl, for Peptide Synthesis
スポンサーリンク
概要
- 論文の詳細を見る
The properties of two aspartic acid β-esters (Asp(OR), R=cycloheptyl (Chp) and cyclooctyl(Coc)) were examined. These two protecting groups were found to be stable to trifluoroacetic acid(0℃, 2 h), but were cleaved by HF or 1 M trifluoromethanesulfonic acid-thioanisole in trifluoro-acetic acid (0℃, 60 min). Using a model peptide, Z(OMe)-Ala-Asp(OR)-Gly-OBzl, the behavior of the Asp(OR) residue with base or acid was examined. These esters were less susceptible to succinimide formation than the Bzl group in Et_3N treatment. In acid deprotection, succinimide formation from these peptides was less than 7% in both cases.
- 公益社団法人日本薬学会の論文
- 1986-02-25
著者
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藤井 信孝
京都大学薬学部
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二木 史朗
徳島大学薬学部
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二木 史朗
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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大高 章
Faculty of Pharmaceutical Sciences, Kyoto University
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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船越 奨
Faculty of Pharmaceutical Sciences
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野水 基義
Faculty of Pharmaceutical Sciences
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赤路 健一
Faculty of Pharmaceutical Sciences
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大高 章
京都大学 薬
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野水 基義
Faculty Of Pharmaceutical Sciences Kyoto University
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大高 章
京大 大学院薬学研究科
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矢島 治明
京都大学
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船越 奨
Faculty Of Pharmaceutical Sciences Kyoto University
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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渡辺 和英
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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二木 史朗
Faculty Of Pharmaceutical Sciences Kyoto University
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藤井 信孝
京都大学
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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