抗アレルギー薬の研究(第1報)1,2,3-三置換-2-propen-1-one類, 3,4-二置換-4-oxo-2-butenoic Acid類及び関連化合物について

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概要

• 論文の詳細を見る

• A new series of 1,2,3-trisubstituted-2-propen-1-one derivatives (9a-v, 10a-j, 13a-c, 14a-j) and 3,4-disubstituted-4-oxo-2-butenoic acids (6a-i, 7a-n) with azole compounds were synthesized. Inhibitory activities against rat passive cutaneous anaphylaxis (PCA) reaction and histamine release from rat mast cells were tested. The ester derivatives (7a-n, 14a-j) exhibited a more potent inhibitory activity against histamine release compared with alkylamine (9a-v), β-hydroxyethoxy (10a-j) and carboxylic acid (6a-i, 13a-c) derivatives, but somewhat weaker in their anti-PCA activity. Structure-activity relationships were discussed.

• 社団法人日本薬学会の論文
• 1990-10-25

著者

• 井上 幸子

  四国化成工業株式会社

• 平尾 浩彦

  四国化成工業株式会社

• 藤田 孝行

  四国化成工業株式会社

• 岩崎 好也

  四国化成工業株式会社

• 井出 寿男

  四国化成工業株式会社

• 北川 幸己

  徳島大学薬学部

• 二木 史朗

  徳島大学薬学部

• 川西 弘文

  徳島大学薬学部

• 秋田 正

  徳島大学薬学部

• 二木 史朗

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 二木 史朗

  Faculty Of Pharmaceutical Sciences Kyoto University

• 平尾 浩彦

  四国化成工業

関連論文

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