Studies on Peptides. CXLIII. : Evaluation of β-Methylaspartate for Peptide Synthesis
スポンサーリンク
概要
- 論文の詳細を見る
The β-l-menthyl ester of aspartic acid, Asp(OMen), was found to be stable to trifluoroacetic acid (TFA) in an ice-bath for 3h, but to be cleaved by HF or 1M trifluoromethanesulfonic acid-thioanisole in TFA in an ice-bath within 60 min. Asp(OMen) was employed for the synthesis of tetragastrin, for which the use of disphenylsulfide, as an additional scavenger, is recommended to accelerate the acidolytic cleavage of this protecting group. This protecting group is superior to other available protecting groups so far examined in terms of suppression of base-catalyzed succinimide formation.
- 社団法人日本薬学会の論文
- 1986-10-25
著者
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藤井 信孝
京都大学薬学部
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二木 史朗
徳島大学薬学部
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二木 史朗
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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大高 章
Faculty of Pharmaceutical Sciences, Kyoto University
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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別所 清
Faculty Of Pharmaceutical Sciences Kyoto University
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船越 奨
Faculty of Pharmaceutical Sciences
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赤路 健一
Faculty of Pharmaceutical Sciences
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大高 章
徳島大学大学院ヘルスバイオサイエンス研究部
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大高 章
京都大学 薬
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山下 武美
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
京都大学
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船越 奨
Faculty Of Pharmaceutical Sciences Kyoto University
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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二木 史朗
Faculty Of Pharmaceutical Sciences Kyoto University
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山下 武美
Faculty Of Pharmaceutical Sciences Kyoto University
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藤井 信孝
京都大学
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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