2-Propen-1-one 誘導体の合成と抗真菌活性^<1)>

スポンサーリンク

概要

• 論文の詳細を見る

• New active antifungal agents containing 1,1-disubstituted ethylenes (No.1-5), 1,2-disubstituted ethylenes (No.6-9) and substitued 2-propen-1-one derivatives (No.10-68) with azole compounds were prepared and structure-activity relationships were presented.(Z)-1-(4-Chloropheny1)-3-(2,4-dichloropheny1)-2-(1H-imidazol-1-y1)-2-propen-1-one hydrochloride (No.21), (Z)-1- (5-chloro-2-thieny1)-3-(4-chloropheny1)-2-(1H-imidazol-1-y1)-2-propen-1-one (No.55) and (Z)-1-(5-chloro-2-thienyl)-3-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-2-propen-1-one (No.56) displayed potent broad-spectrum activity not only against dermatophytes but also against yeast cells (Candida albicans).

• 社団法人日本薬学会の論文
• 1988-10-25

著者

• 平尾 浩彦

  四国化成工業株式会社

• 藤田 孝行

  四国化成工業株式会社

• 岩崎 好也

  四国化成工業株式会社

• 北川 幸己

  徳島大学薬学部

• 二木 史朗

  徳島大学薬学部

• 秋田 正

  徳島大学薬学部

• 二木 史朗

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 矢部 浩子

  四国化成工業株式会社

• 井上 智弘

  徳島大学薬学部

• 松崎 敬之

  徳島大学薬学部

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 二木 史朗

  Faculty Of Pharmaceutical Sciences Kyoto University

• 平尾 浩彦

  四国化成工業

関連論文

• 抗アレルギー薬の研究(第1報)1,2,3-三置換-2-propen-1-one類, 3,4-二置換-4-oxo-2-butenoic Acid類及び関連化合物について
• Studies on Peptides. Application of Trifluoromethanesulphonic Acid as a Deblocking Reagent to the Synthesis of Neurotensin
• Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of α-Form of Rat Calcitonin Gene-Related Peptide (α-rCGRP)(Organic,Chemical)
• Solution Synthesis of Human Peptide YY (hPYY)
• Solution Synthesis of Human Neuropeptide Y (hNPY)
• 2-Propen-1-one 誘導体の合成と抗真菌活性^
• Studies on Peptides. CXXXVI. : Solution-Phase Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Calcitonin Gene-Related Peptide (hCGRP)
• Tyr-Arg(キョートルフィン)ユニットを持つ新鎮痛性ペンタペプチド、ネオキョートルフィンの牛脳よりの単離(発表論文抄録(1983年))
• Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin
• Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide
• Synthesis and Analgesic Activity of Neo-kyotorphin Analogs
• ウシ脳からの麻酔作用を持つ新たなペンタペプチド, Neo-Kyotorphinの単離
• Studies on Peptides. XLIII. Synthesis of Two Protected Peptides Related to the C-Terminal Portion of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
• Studies on Peptides. CXLIII. : Evaluation of β-Methylaspartate for Peptide Synthesis
• Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements
• A Deblocking Method using Thioether-Sulfonic Acid Systems. Application to the Synthesis of Met-Enkephalin
• Studies on Peptides. CXXXII. : Evaluation of Two β-Carboxyl Protecting Groups of Aspartic Acid, Cycloheptyl and Cyclooctyl, for Peptide Synthesis
• Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)
• Synthesis of Canine Motilin, a Gastric Motor Activity-Stimulating Polypeptide, and Its N^1-Substituted Analogs
• Studies on Peptides. CLX. : Synthesis of a 33-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Cholecystokinin (hCCK-33)
• Enzyme Immunoassay of a Substance P-like Immunoreactive Substance in Human Plasma and Saliva
• Studies on Peptides. CLIX. : Preparation of a Protected 33-Residue Peptide for the Synthesis of Human Cholecystokinin (hCCK-33)
• Synthesis of the Hexadecapeptide corresponding to Positions 1 through 16 of Porcine Motilin, a Gastric Motor Activity Stimulating Polypeptide
• Studies on Peptides. CXXIX. Application of N^-Mesitylenesulfonyl-tryptophan for the Syntheses of Neuromedin B and Neuromedin C
• 第31回ペプチド化学討論会
• Facile Reduction of Methionine Sulfoxide with Sulfur Trioxide/Iodide Ion System
• Solution Syntheses of Two Enkephalin-Containing Peptides, Peptide E and Dynorphin(1-24), Using N^-(2,4,6-Triisopropylphenylsulfonyl)tryptophan
• Alternative Synthesis of Porcine Secretin and Apparent Autolysis of the Product
• SYNTHESIS OF A NEWLY ISOLATED OPIOID TRIDECAPEPTIDE, RIMORPHIN, FROM PITUITARY USING A TRIFLUOROACETIC ACID-THIOANISOLE DEPROTECTION SYSTEM
• Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the N^-Function of Histidine
• Synthesis and Activity of C-Terminal Heptapeptides of Tachykinins and Bombesin-like Peptides
• Synthesis of Two Substance P Analogs, [8-Tyr] and [5-Asn] Substance P
• Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine
• Studies on Peptides. LXV. Conventional Synthesis of a New Hypothalamic Peptide, Bovine Neurotensin
• 合成ペプチドによるイオンチャネル機能の創出
• Studies on Peptides. CXXII. N-Succinimidyl-p-(2-nitrovinyl)-benzoate and Its m-Isomer, as Heterobifunctional Conjugating Reagents for Immunoassay
• Studies on Peptides. CXXI. N^-Mesitylenesulfonyl-tryptophan, a New Derivative for Peptide Synthesis
• Alternative Synthesis of Substance P
• Studies on Peptides. LVIII. Synthesis of Tyr^1-Substance P
• ラクトアミドおよびマンデルアミドとアミノ酸およびアミンとの融解反応
• Studies on Peptides. XXXVII. Suppressed Racemization in Peptide Synthesis by the Use of p-Chloro or p-Nitrobenzene-sulfohydroxamic Acid
• Studies on Peptides. XXXVIII. Structure-Activity Correlations in Substance P
• Studies on Peptides. XXXIV. Conventional Synthesis of the Undecapeptide Amide corresponding to the Entire Amino Acid Sequence of Bovine Substance P
• ハロゲノメチル基をもつアミノアルコールおよびアミノジオールの合成
• Fmoc固相合成法による硫酸化チロシン含有ペプチドの直接合成法の開発
• “Safety-catch”型保護基の特性を活用した硫酸化チロシン含有ペプチドの新規合成法の開発
• Evaluation of the Final Deprotection System for the Solid-Phase Synthesis of Tyr(SO_3H)-Containing Peptides with 9-Fluorenylmethyloxycarbonyl (Fmoc)-Strategy and Its Application to the Synthesis of Cholecystokinin (CCK)-12
• 次世代水溶性プレフラックス
• 塗料用架橋剤としての「CIC酸」について

もっと見る 閉じる

スポンサーリンク