Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)
スポンサーリンク
概要
- 論文の詳細を見る
Seven peptide fragments were synthesized by known amide-forming reactions as building blocks for the solution-phase synthesis of the heptatriacontapeptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP). S-1-Adamantyl-cysteine [O. Nishimura, C. Kitada, and M. Fujino, Chem. Pharm. Bull., 26,1576 (1978)] was employed, together with amino acid derivatives bearing protecting groups removable by 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid.
- 公益社団法人日本薬学会の論文
- 1986-02-25
著者
-
藤井 信孝
京都大学薬学部
-
北川 幸己
徳島大学薬学部
-
大高 章
Faculty of Pharmaceutical Sciences, Kyoto University
-
藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
-
矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
-
北川 幸己
Faculty of Pharmaceutical Sciences, Kyoto University
-
安藤 健司
Faculty of Pharmaceutical Sciences, Tokushima University
-
川元 達彦
Faculty of Pharmaceutical Sciences, Tokushima University
-
秋田 正
Faculty of Pharmaceutical Sciences, Tokushima University
-
船越 奨
Faculty of Pharmaceutical Sciences
-
野水 基義
Faculty of Pharmaceutical Sciences
-
赤路 健一
Faculty of Pharmaceutical Sciences
-
秋田 正
Faculty Of Pharmaceutical Sciences The University Of Tokushima
-
北川 幸己
Faculty Of Pharmaceutical Sciences University Of Tokushima
-
安藤 健司
Faculty Of Pharmaceutical Sciences Tokushima University
-
大高 章
京都大学 薬
-
野水 基義
Faculty Of Pharmaceutical Sciences Kyoto University
-
大高 章
京大 大学院薬学研究科
-
矢島 治明
京都大学
-
船越 奨
Faculty Of Pharmaceutical Sciences Kyoto University
-
矢島 治明
京大・薬
-
藤井 信孝
京大 薬
-
矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
-
藤井 信孝
京都大学
-
赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
-
川元 達彦
Faculty Of Pharmaceutical Sciences The University Of Tokushima
関連論文
- O-80 膵癌の浸潤転移におけるStromal Derived Factor-1 (SDF-1)の関与について
- 抗アレルギー薬の研究(第1報)1,2,3-三置換-2-propen-1-one類, 3,4-二置換-4-oxo-2-butenoic Acid類及び関連化合物について
- Solution-Phase Synthesis of an Anti-human Immunodeficiency Virus Peptide, T22 ([Tyr^, Lys^7]-Polyphemusin II), and the Modification of Trp by the p-Methoxybenzyl Group of Cys during Trimethylsilyl Trifluoromethanesulfonate Deprotection
- Molecular Parameters for the Anti-Human Immunodeficiency Virus Activity of T22 ([Tyr^, Lys^7]-Polyphemusin II)
- HIV感染のコレセプター,CXCR4,を標的とした抗HIV薬の開発
- Studies on Peptides. Application of Trifluoromethanesulphonic Acid as a Deblocking Reagent to the Synthesis of Neurotensin
- 膵癌におけるKiSS-1およびその受容体の発現と遊走能への関与
- Synthesis of Protegrin-Related Peptides and Their Antibacterial and Anti-human Immunodeficiency Virus Activity
- Solution Synthesis of Human Neuropeptide Y (hNPY)
- 2-Propen-1-one 誘導体の合成と抗真菌活性^
- Studies on Peptides. CXXXVI. : Solution-Phase Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Calcitonin Gene-Related Peptide (hCGRP)
- Studies on Peptides. LXXVI. Synthesis of Kassinin, a New Frog Skin Peptide
- Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
- Studies on Peptides. LXIX. Selective Removal of Acid Labile α-Amino Protecting Groups with Dilute Sulfonic Acids
- Studies on Peptides. XLVIII. Application of the Trifluoromethanesulphonic Acid Procedure to the Synthesis of Tuftsin
- Tyr-Arg(キョートルフィン)ユニットを持つ新鎮痛性ペンタペプチド、ネオキョートルフィンの牛脳よりの単離(発表論文抄録(1983年))
- Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin
- Studies on Peptides. CXLI. : Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Porcine GIP (Glucose-Dependent Insulinotropic Polypeptide)
- Studies on Peptides. CXXXIX. : Solution Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Glucose-Dependent Insulinotropic Polypeptide (GIP)
- Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide
- Studies on Peptides. CXXXI. Synthesis of Adrenorphin and Enkephalin Analogs
- Synthesis and Analgesic Activity of Neo-kyotorphin Analogs
- ウシ脳からの麻酔作用を持つ新たなペンタペプチド, Neo-Kyotorphinの単離
- Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis
- Enzyme Immunoassay of Somatostatin (SS)-like Immunoreactive Substance in Bovine Milk
- Studies on Peptides. CLVI. Synthesis of Second Human Calcitonin Gene-Related Peptide (β-hCGRP) by Application of a New Disulfide-Bonding Reaction with Thallium(III) Trifluoroacetate(Organic,Chemical)
- Studies on Peptides. CXLII. : Synthesis of Des-1-Ala-des-α-amino-Human Calcitonin Gene-Related Peptide
- Studies on Peptides. XLIII. Synthesis of Two Protected Peptides Related to the C-Terminal Portion of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
- Synthesis of Optically Pure 2-Aziridinemethanols : Versatile Synthetic Building Blocks
- Studies on Peptides. CXLVI. : Synthesis of Gln^-Motilin and Examination of Its Immunological Properites
- Studies on Peptides. CXXX. Convenient Procedure for the Reduction of Methionine Sulfoxide
- Studies on Peptides. CLI. Syntheses of Cystine-Peptides by Oxidation of S-Protected Cysteine-Peptides with Thallium(III) Trifluoroacetate(Organic,Chemical)
- Studies on Peptides. CXLIII. : Evaluation of β-Methylaspartate for Peptide Synthesis
- Growth Factor
- 第5回メディシナルケミストリーシンポジウム
- 有機スルホン酸脱保護法によるペプチドの合成研究
- Synthesis of a Heptacosapeptide Amide corresponding to the Entire Amino Acid Sequence of Chicken Gastrin Releasing Peptide (GRP)
- Synthesis of a Heptacosapeptide Amide corresponding to the Entire Amino Acid Sequence of Gastric Gastrin Releasing Peptide
- A Deblocking Method using Thioether-Sulfonic Acid Systems. Application to the Synthesis of Met-Enkephalin
- Selective Transport of the Salts of Amino Acid Esters through an Organic Liquid Membrane with Antamanide as a Carrier
- Studies on Peptides. CXLVIII. : Application of a New Deprotecting Procedure with Trimethylsilyl Trifluoromethanesulfonate for the Syntheses of Two Porcine Spinal Cord Peptides, Neuromedin U-8 and Neuromedin U-25(Amaryllidaceae)(Organic,Chemical)
- Studies on Peptides. CLXVI. : Solid-Phase Syntheses and Immunological Properties of Fragment Peptides Related to Human Hepatitis B Virus Surface Antigen (HBsAg) and Its Pre-S2 Gene
- Studies on Peptides. CLVII. : Synthesis of a Frog-Skin Peptide, Sauvagine
- Studies on Peptides. CXXXII. : Evaluation of Two β-Carboxyl Protecting Groups of Aspartic Acid, Cycloheptyl and Cyclooctyl, for Peptide Synthesis
- Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)
- Studies on Peptides. CXXIV. Solution Synthesis of the Hentetracontapeptide Amide Corresponding to the Entire Amino Acid Sequence of Human Corticotropin Releasing Factor (hCRF)
- Studies on Peptides. CXXIII. Preparations of Nine Peptide Fragments for the Synthesis of Human Corticotropin Releasing Factor (hCRF)
- SYNTHESIS OF A HENTETRACONTAPEPTIDE AMIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN CORTICOTROPIN RELEASING FACTOR (hCRF)
- Studies on Peptides. CXVII. Solution Synthesis of the Tetratetracontapeptide Amide Corresponding to the Entire Amino Acid Sequence of Growth Hormone Releasing Factor, Somatocrinin
- SOLUTION SYNTHESIS OF A TETRATETRACONTAPEPTIDE AMIDE WITH GROWTH HORMONE RELEASING ACTIVITY
- Studies on Peptides. CXXXVIII. : Conventional Solution Synthesis of Bovine Hypothalamic Growth Hormone Releasing Factor (bGRF)
- Studies on Peptides. CXXXVII. : Conventional Solution Synthesis of Porcine Hypothalamic Growth Hormone Releasing Factor (pGRF)
- Synthesis of Canine Motilin, a Gastric Motor Activity-Stimulating Polypeptide, and Its N^1-Substituted Analogs
- Studies on Peptides. CLXIV. : Solution-Phase Synthesis of a 36-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Chicken Antral Peptide
- Studies on Peptides. CLX. : Synthesis of a 33-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Cholecystokinin (hCCK-33)
- Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs
- Acceleration of the N^α-Deprotection Rate by the Addition of m-Cresol to Diluted Methanesulfonic Acid and Its Application to the Z(OMe)-Based Solid-Phase Syntheses of Human Pancreastatin-29 and Magainin 1
- Enzyme Immunoassay of a Substance P-like Immunoreactive Substance in Human Plasma and Saliva
- Micro-Enzyme Immunoassay of Vasoactive Untestinal Polypeptide (VIP)-like Immunoreactive Substance in Bovine Milk
- Studies on Peptides. CLXVIII. : Syntheses of Three Peptides Isolated from Horseshoe Crab Hemocytes, Tachyplesin I, Tachyplesin II, and Polyphemusin I
- Studies on Peptides. CLXVII. / Solid-Phase Syntheses and Immunological Properties of Fragment Peptides Related to Human Malaria Circumsporozoite Protein
- Immuno-affinity Purification of Specific Antibodies against Vasoactive Intestinal Polypeptide (VIP) on VIP (1-10)-Linked Polydimethylacrylamide Resin
- S-BENZYLOXYMETHYLCYSTEINE, ITS PROPERTIES AND APPLICATION IN THE SYNTHESIS OF PORCINE BRAIN NATRIURETIC PEPTIDE (pBNP)
- Studies on Peptides. CLXV. : Combination of a New Amide-Precursor Reagent and Trimethylsilyl Bromide Deprotection for the 9-Fluorenylmenthyloxycarbonyl-Based Solid-Phase Synthesis of chicken Antral Peptide
- Studies on Peptides. CLXIII. : Synthesis of Guinea Pig Vasoactive Intestinal Polypeptide(gVIP)
- Studies on Peptides. CLXII. : Synthesis of Chicken Calcitonin-Gene-Related Peptide (cCGRP) by Application of Sulfoxide-Directed Disulfide-Bond-Forming Reaction
- Studies on Peptides. CLIX. : Preparation of a Protected 33-Residue Peptide for the Synthesis of Human Cholecystokinin (hCCK-33)
- Partical Structural Revision of Porcine Pancreatic Colipase
- Studies on Peptides. CVI. Synthesis of a Physalaemin-like Peptide, [Lys^5,Thr^6]-Physalaemin, isolated from the Skin of a Frog, Uperoleia rugosa
- Enzyme Immunoassay of Thyrotropin Releasing Hormone (TRH)
- Apparent Autolysis of the N-Terminal Tetrapeptide of Vasoactive Intesinal polypeptide (VIP)
- Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide
- Investigation of the Dimethylsulfoxide-Trifluoroacetic Acid Oxidation System for the Synthesis of Cystine-Containing Peptides
- Synthetic Study on Selenocystine-Contaning Peptides
- Synthesis of the Hexadecapeptide corresponding to Positions 1 through 16 of Porcine Motilin, a Gastric Motor Activity Stimulating Polypeptide
- Studies on Peptides. CXXIX. Application of N^-Mesitylenesulfonyl-tryptophan for the Syntheses of Neuromedin B and Neuromedin C
- 上皮細胞増殖因子の活性を持つペプチドの合成
- Studies on Peptides. CXXVII. Synthesis of a Tripentacontapeptide with Epidermal Growth Factor Activity
- Studies on Peptides. CXII. Alternative Synthesis of Heptacosapeptide, a New Gastrointestinal Polypeptide
- Studies on Peptides. LXXIV. Convenient Procedure for the Preparation of Methionine Sulphoxide Derivatives
- Studies on Peptides. LXXII. Examination of the N^ε-Alkylation of Lysine in the Methanesulphonic Acid Procedure for Peptide Synthesis
- Alternative Synthesis of Porcine Secretin and Apparent Autolysis of the Product
- SYNTHESIS OF A NEWLY ISOLATED OPIOID TRIDECAPEPTIDE, RIMORPHIN, FROM PITUITARY USING A TRIFLUOROACETIC ACID-THIOANISOLE DEPROTECTION SYSTEM
- Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the N^-Function of Histidine
- Synthesis and Activity of C-Terminal Heptapeptides of Tachykinins and Bombesin-like Peptides
- Synthesis of Two Substance P Analogs, [8-Tyr] and [5-Asn] Substance P
- Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine
- 奨励賞受賞 山田健一氏の業績
- 薬学会賞受賞 伊藤信行氏の業績
- Alternative Synthesis of Substance P
- Studies on Peptides. LVIII. Synthesis of Tyr^1-Substance P
- Studies on Peptides. CXLIX. : Solid-Phase Synthesis of a Rabbit Stomach Peptide by Application of a New Polymer Support and a New Deprotecting Procedure(Organic,Chemical)
- シスチン含有ペプチドの新規合成法
- ラクトアミドおよびマンデルアミドとアミノ酸およびアミンとの融解反応
- Studies on Peptides. XXXVII. Suppressed Racemization in Peptide Synthesis by the Use of p-Chloro or p-Nitrobenzene-sulfohydroxamic Acid
- Studies on Peptides. XXXVIII. Structure-Activity Correlations in Substance P
- Studies on Peptides. XXXIV. Conventional Synthesis of the Undecapeptide Amide corresponding to the Entire Amino Acid Sequence of Bovine Substance P
- “Safety-catch”型保護基の特性を活用した硫酸化チロシン含有ペプチドの新規合成法の開発
- 奨励賞受賞 大石真也氏の業績
- 学術振興賞受賞 竹本佳司氏の業績