Molecular Parameters for the Anti-Human Immunodeficiency Virus Activity of T22 ([Tyr^<5,12>, Lys^7]-Polyphemusin II)

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概要

• 論文の詳細を見る

• T22 ([Tyr^<5,12>, Lys^7]-polyphemusin II) was found to exhibit strong anti-human immunodeficiency virus (HIV) activity and exert its effects on a virus-cell fusion process. In the present study, the all-D enantiomer of T22 and its related compounds were synthesized to examine the molecular parameters required for the interaction of T22 with membrane components of cells or viruses in order to exert this anti-HIV activity. The anti-HIV activity of these analogs was investigated in comparison with their membrane permeability with aspect to large unilamellar vesicles (LUVs). The all-D enantiomer of T22 exhibited a 20-fold lower anti-HIV activity compared with T22,whereas they both showed the same membrane permeability. No positive correlation between anti-HIV activity and membrane permeability was observed. These results suggest that the anti-HIV activity of T22 is mediated through the interaction with chiral component (s) of the cell or virus.

• 社団法人日本薬学会の論文
• 1994-12-15

著者

• 山本 直樹

  感染研

• 宮嶋 孝一郎

  Faculty of Pharmaceutical Sciences, Kyoto University

• 井深 俊郎

  Faculty of Pharmaceutical Sciences, Kyoto University

• 中島 秀喜

  Department Of Microbiology Yamanashi Medical University

• 玉村 啓和

  Faculty of Pharmaceutical Sciences, Kyoto University

• 大高 章

  Faculty of Pharmaceutical Sciences, Kyoto University

• 増田 正雄

  Faculty of Pharmaceutical Sciences, Kyoto University

• 村上 努

  Department of Microbiology, Tokyo Medical and Dental University, School of Medicine

• 脇 道典

  SEIKAGAKU Corporation

• 松本 章義

  SEIKAGAKU Corporation

• 山本 直樹

  Department of Microbiology, Tokyo Medical and Dental University, School of Medicine

• 寺川良 司博

  Faculty of Pharmaceutical Sciences, Kyoto University

• 小出 隆規

  Faculty of Pharmaceutical Sciences, Kyoto University

• 松崎 勝已

  Faculty of Pharmaceutical Sciences, Kyoto University

• FUJII Nobutaka

  Faculty of Pharmaceutical Sciences, Kyoto University

• 玉村 啓和

  東医歯大生材工研

• 玉村 啓和

  東京医歯大・生材研

• 大高 章

  徳島大学大学院ヘルスバイオサイエンス研究部

• 大高 章

  京都大学 薬

• 藤井 信孝

  京都大学大学院薬学研究科 医薬創成情報科学専攻

• WAKI Michinori

  SEIKAGAKU Corp.

• 大高 章

  京大 大学院薬学研究科

• 増田 正雄

  Faculty Of Pharmaceutical Sciences Kyoto University

• Masuda Masao

  Faculty Of Pharmaceutical Sciences Kyoto University

• 井深 俊郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• Nakashima H

  Department Of Microbiology Yamanashi Medical University

• Fujii Nobutaka

  Faculty Of Pharmaceutical Science Kyoto University

• Tamamura Hirokazu

  Faculty Of Pharmaceutical Sciences Kyoto University

• Tamamura Hirokazu

  Dept. Of Molecular Recognition Inst. Of Biomaterials And Bioengineering Tokyo Medical And Dental Uni

• Murakami T

  Department Of Microbiology Tokyo Medical And Dental University School Of Medicine

• Tamamura H

  Faculty Of Pharmaceutical Sciences Kyoto University

• Nakashima H

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 小出 隆規

  Faculty Of Pharmaceutical Sciences Kyoto University

• Masada M

  Department Of Biological Science Graduate School Of Science Osaka University

• 宮嶋 孝一郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• 松崎 勝已

  Faculty Of Pharmaceutical Sciences Kyoto University

• 脇 道典

  Seikagaku Corp.

• Tamamura H

  Graduate School Of Pharmaceutical Sciences Kyoto University

• 寺川 良司博

  Faculty Of Pharmaceutical Sciences Kyoto University

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