New Substances against Human Immunodeficienty Virus : Sulfated 5'-Nucleotidase Inhibitory Polyphenols
スポンサーリンク
概要
- 論文の詳細を見る
Two sulfated polyphenols, NF-86II-S-13.3 and NF-86II-S-6.2,were synthesized from NF-86II without sulfer their inhibitory effect on human immunodeficiency virus (HIV) infection in vitro was examined, using cytopathic effect and an antigen expression assay system in MT-4 cells. NF-86II-S-13.3 (sulfur content, 13.3%) completely inhibited the cytopathic effect of HIV nad the HIV -specific antigen expression in MT-4 cells at concentrations of more than 6.3 μg/ml. The effect of NF-86II-S-6.2 (sulfur content, 6.2%) was much weaker than that of NF-86IIS-13.3. On the other hand, NF-86II without sulfur did not show any activity at all.
- 社団法人日本薬学会の論文
- 1992-03-25
著者
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山本 直樹
感染研
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中島 秀喜
Department Of Microbiology Yamanashi Medical University
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山本 直樹
Department of Microbiology, Tokyo Medical and Dental University, School of Medicine
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東海林 敏勝
Central Laboratory, Nippon Flour Mills Co., Ltd.
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内野 敬二郎
Central Laboratory, Nippon Flour Mills Co., Ltd.
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水野 隆志
Central Laboratory, Nippon Flour Mills Co., Ltd.
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小河原 宏
Department of Biochemistry, Meiji College of Pharmacy
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水野 隆志
日本製粉(株)中研
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内野 敬二郎
Central Laboratory Nippon Flour Mills Co. Ltd.
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東海林 敏勝
Central Laboratory Nippon Flour Mills Co. Ltd.
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