Effect of the Interaction of Drug-β-Cyclodextrin Complex with Bile Salts on the Drug Absorption from Rat Small Intestinal Lumen
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概要
- 論文の詳細を見る
This investigation was concerned with the change of the bioavailability of a drug owing to the interaction of the drug-β-cyclodextrin complex with bile salts in rat intestinal lumen. The absorption of sulfamethizole (SMZ) from rat intestinal lumen after administration of SMZ-β-cyclodextrin complex was determined by a closed-loop method in the presence of absence of bile. The blood level of SMZ after administration of SMZ-β-cyclodextrin complex was significantly decreased in comparison with that after administration of SMZ alone in bile duct-ligated rats. On the other hand, the blood level of SMZ after SMZ-β-cyclodextrin administration in intact rats (bile duct non-ligated) or on the addition of sodium cholate was similar to the level in the case of SMZ alone. Thus, bile salts were found to act as a competing agent in the gastrointestinal tract.
- 社団法人日本薬学会の論文
- 1989-01-25
著者
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宮嶋 孝一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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政田 幹夫
Faculty of Pharmaceutical Sciences, Setsunan University
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中西 邦夫
Faculty of Pharmaceutical Sciences, Setsunan University
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灘井 種一
Faculty of Pharmaceutical Sciences, Setsunan University
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政田 幹夫
Department Of Hospital Pharmacy Fukui Medical School
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中西 邦夫
Faculty Of Pharmaceutical Sciences Setsunan University
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政田 幹夫
福井医科大学附属病院薬剤部
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灘井 種一
Faculty Of Pharmaceutical Sciences Setsunan University
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灘井 種一
Faculty Of Pharmaceutical Science Josai University
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宮嶋 孝一郎
Faculty Of Pharmaceutical Sciences Kyoto University
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