COMPLEX FORMATION BETWEEN DI-AND MONOPHOSPHATIDYLCHOLINES AND CYCLODEXTRINS IN WATER
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概要
- 論文の詳細を見る
α-, β- and γ-Cyclodextrins (CDs) interact with phospholipid membranes causing an appreciable decrease in the surface pressure of monolayer films of dimyristoylphosphatidylcholine and a leakage of the marker, calcein, in the inner aqueous phase of a liposome which is composed of diacylphosphatidylcholine (DAPC) and dicetylphosphate. The α- and γ-CDs form white amorphous solids with DAPC in the unilamellar state in aqueous solutions. These solids consist of CD and DAPC. The molar ratio of CD to DAPC depends on the kinds of CD and the acyl chain length of DAPC. From the composition of the CD-DAPC complex, several molecules of CD include two acyl chains of DAPC to make complexes such as alkanoic acid-CD complexes.
- 公益社団法人日本薬学会の論文
- 1985-06-25
著者
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宮嶋 孝一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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中垣 正幸
Faculty of Pharmaceutical Sciences, Kyoto University
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中垣 正幸
東京コロイド科学研究所
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宮嶋 孝一郎
京大・薬
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富田 恵子
京都大学 薬
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中垣 正幸
Tokyo Insitute Of Colloid Science
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宮嶋 孝一郎
Faculty Of Pharmaceutical Sciences Kyoto University
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富田 恵子
Faculty of Pharmaceutical Sciences, Kyoto University
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