Hydrolysis of Diphosphate Ion to Orthophosphate Ion in the Presence of Calcium Ion. Fundamental Study of the Development of the Mixed Crystal Deposition Disease(Physical,Chemical)

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The hydrolysis of diphosphate ion (pyrophosphate ion, Ppi) to orthophosphate ion (Pi) in the presence of Ca^<2+> in aqueous systems were examined. The systems studied were (1) K_4P_2P_7+CaCl_2 with/without KOH, (2) K_4P_2O_7+Ca(OH)_2, (3) aqueous suspension of the precipitate isolated from the mother solution immediately after mixing of K_4P_2O_7 and CaCl_2, and (4) K_4P_2O_7 in an aqueous suspension of Ca_2P_2O_7. It was found that the gradual release of Ca^<2+> to the aqueous phase from the Ca^<2+>-reservoir (i.e., Ca(OH)_2 formed (system 1) or added (system 2)) is effective for the hydrolysis of Ppi. When the temporary precipitate containing Ppi was suspended in the aqueous phase (system 3), the hydrolysis of Ppi was delayed because re-dissolution of the precipitate was necessary prior to the hydrolysis. The result in system 4 suggested that the hydrolysis reaction occurs on the surface of Cu_2P_2O_7. These results are discussed in connection with a possible physicochemical mechanism of deposition of mixed crystals(calcium diphosphate and calcium orthophosphate) in the human body, causing mixed crystal deposition disease.
公益社団法人日本薬学会の論文
1987-06-25