ヒドロキシアパタイトの分散性に及ぼすコンドロイチン硫酸イオンとカルシウムイオンの添加の影響

概要

論文の詳細を見る
Optical density (OD), as an index for the suspension stability of hydroxyapatite (HAP ; 5g/dl), was measured at 550 nm in an aqueous solution of CaCl_2 mixed with sodium chondroitin-6-sulfate (Na_2Chs). The contour lines for OD with respect to concentrations of CaCl_2 and Na_2Chs were obtained. It was found that the suspension stability of HAP decreases with an increase in concentration of CaCl_2,but increases with an increase in concentration of Na_2Chs. It was concluded that HAP suspension is stabilized mainly by virtue of steric hindrance effect and inter-particle electrostatic repulsion effect of negatively charged segments of adsorbed Chs, even though ionic strength is high and the net charge of HAP particles becomes positive (i.e., the amount of adsorbed Ca^<2+> is larger than that of adsorbed Chs).
公益社団法人日本薬学会の論文
1984-10-25