懸濁粒子の沈積状態に関する物理化学的研究(第5報)グリセオフルビンの分散および沈積状態に及ぼすメチルセルロースおよびドデシル硫酸ナトリウムの作用に関する研究

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Effects of methylcellulose and sodium dodecyl sulfate (SDS) on the dispersion and sedimentation bed of Griseofulvin (GR) was examined by the measurement of apparent degree of aggegation (γ_m/γ_o), amount of adsorption (X), ζ-Potential, porosity (ε), and tortxosity (q) of the sedimentation bed. When methylcellulose was added to the suspension prepared in water or SDS solution, γ_m/γ_o and ε decreased and q increased with the increasing amount of methylcellulose added in the case of water and 0.8 mM SDS solution, while each of the above quantities remained constant in 8 mM SDS solution. The ζ-potential in 10 mM NaCl decreased with the increase of methylcellulose, but gave a constant value against methylcellulose in the presence of SDS. The amount of methylcellulose adsorbed decreased with the increase of SDS concentration, and adsorption was not observed in 8 mM SDS solution. When SDS was added to the suspension prepared in water or methylcellulose solution, γ_m/γ_o and ε decreased and q increased with the increasing amount of SDS added in the case of water, while these values showed a maximum value against the SDS concentration at about 2.5 mM in the case of a suspension prepared in methylcellulose solution. The ζ-potential increased with the increase of SDS concentration in water or methylcellulose solution. Amount of SDS adsorbed was almost equal in both water and methylcellulose solution. Vertical tortuosity, qv, showed a higher value than horizontal tortuosity, qM, in all cases, and they were almost equal in concentrated dispersant solxtion. All the data plotted to see the relation between q and ε fell on the same line, showing that q decreased with the increase of ε. qv/qM took the value near 1 and increased with the increase of ε.
公益社団法人日本薬学会の論文
1976-09-25

懸濁粒子の沈積状態に関する物理化学的研究(第5報)グリセオフルビンの分散および沈積状態に及ぼすメチルセルロースおよびドデシル硫酸ナトリウムの作用に関する研究

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